Sun JY, Li C, Du FY. Adenylate cyclase activates the cAMP signalling pathway to enhance platelet-rich plasma-treated Achilles tendon disease, a theoretical bioinformatics-based study. World J Orthop 2024; 15(2): 192-200 [PMID: 38464349 DOI: 10.5312/wjo.v15.i2.192]
Corresponding Author of This Article
Feng-Ying Du, MD, Doctor, Department of Gastroenterological Surgery, Shandong Provincial Hospital of Shandong First Medical University, No. 324 Jingwu Road, Jinan 250021, Shandong Province, China. sdudfy@126.com
Research Domain of This Article
Orthopedics
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Orthop. Feb 18, 2024; 15(2): 192-200 Published online Feb 18, 2024. doi: 10.5312/wjo.v15.i2.192
Adenylate cyclase activates the cAMP signalling pathway to enhance platelet-rich plasma-treated Achilles tendon disease, a theoretical bioinformatics-based study
Jing-Yi Sun, Cai Li, Feng-Ying Du
Jing-Yi Sun, Cai Li, College of Basic Medical Science, Qilu Medical University, Zibo 255300, Shandong Province, China
Feng-Ying Du, Department of Gastroenterological Surgery, Shandong Provincial Hospital of Shandong First Medical University, Jinan 250021, Shandong Province, China
Author contributions: Du FY designed the study; Du FY and Sun JY performed the research; Du FY and Sun JY analysed the data; Sun JY and Li C wrote the manuscript; Du FY and Li C revised the manuscript.
Conflict-of-interest statement: All the authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng-Ying Du, MD, Doctor, Department of Gastroenterological Surgery, Shandong Provincial Hospital of Shandong First Medical University, No. 324 Jingwu Road, Jinan 250021, Shandong Province, China. sdudfy@126.com
Received: October 26, 2023 Peer-review started: October 26, 2023 First decision: December 12, 2023 Revised: December 29, 2023 Accepted: January 16, 2024 Article in press: January 16, 2024 Published online: February 18, 2024
Abstract
The effectiveness of platelet-rich plasma (PRP) for the treatment of Achilles tendon disorders still needs to be evaluated through a series of prospective studies, but genomic analysis can reveal the existence of complementary PRP treatment options. Based on the 96 platelet activation-related genes in the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, we performed Gene Ontology functional enrichment analysis and KEGG enrichment analysis, pathway correlation analysis, and enrichment mapping to determine the enrichment results of the gene set enrichment analysis and found that the cAMP signalling pathway may be the key to enhancing the effectiveness of PRP treatment. The cAMP signalling pathway interacts with the Rap1 signalling pathway and cGMP-PKG signalling pathway to mediate the entire pathophysiological process of Achilles tendon disease. Moreover, ADCY1-9 may be the key to the activation of the cAMP signalling network. Further based on the data in the Gene Expression Omnibus database, it was found that ADCY4 and ADCY7 may be the players that play a major role, associated with the STAT4-ADCY4-LAMA5 axis and the GRbeta-ADCY7-SEMA3C axis, which is expected to be a complementary target for enhancing the efficacy of PRP in the treatment of Achilles tendon disease.
Core Tip: The cAMP signalling pathway may be the key to enhancing the effectiveness of platelet-rich plasma (PRP) in the treatment of Achilles tendon disease. ADCY1-9 may be the key to activating the cAMP signalling network and is expected to be a complementary target for enhancing the effectiveness of PRP in the treatment of Achilles tendon disease.
