Lin HY, Tan QH. Metagenomic next-generation sequencing may assist diagnosis of osteomyelitis caused by Mycobacterium houstonense: A case report. World J Orthop 2024; 15(11): 1095-1100 [PMID: 39600859 DOI: 10.5312/wjo.v15.i11.1095]
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Orthop. Nov 18, 2024; 15(11): 1095-1100 Published online Nov 18, 2024. doi: 10.5312/wjo.v15.i11.1095
Metagenomic next-generation sequencing may assist diagnosis of osteomyelitis caused by Mycobacterium houstonense: A case report
Quan-Hui Tan, Hong-Yin Lin
Hong-Yin Lin, Quan-Hui Tan, Department of Infectious Disease, Shanghai Sixth People's Hospital, Shanghai 200233, China
Author contributions: Tan QH and Lin HY collaboratively collected data and authored this paper.
Supported byThe National Natural Science Foundation of China, No. 82100631.
Informed consent statement: The issuance of this article was granted informed consent by the patient.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Received: May 5, 2024 Revised: August 22, 2024 Accepted: September 23, 2024 Published online: November 18, 2024 Processing time: 194 Days and 4.3 Hours
Abstract
BACKGROUND
Mycobacterium houstonense (M. houstonense) belongs to the nontuberculous mycobacterium group. Infection caused by M. houstonense is prone to recurrence.
CASE SUMMARY
We present a patient who was diagnosed with osteomyelitis caused by M. houstonense and treated with a combination of cefoxitin, and amikacin combined with linezolid.
CONCLUSION
The emergence of metagenomic next-generation sequencing (NGS) has brought new hope for the diagnosis and treatment of listeria meningitis. NGS can analyze a large number of nucleic acid sequences in a short time and quickly determine the pathogen species in the sample. Compared with traditional cerebrospinal fluid culture, NGS can greatly shorten the diagnosis time and provide strong support for the timely treatment of patients. Regarding treatment, NGS can also play an important role. Rapid and accurate diagnosis can enable patients to start targeted treatment as soon as possible and improve the treatment effect. At the same time, by monitoring the changes in pathogen resistance, the treatment plan can be adjusted in time to avoid treatment failure.
Core Tip: Both the diagnosis and treatment of Mycobacterium houstonense osteomyelitis are challenging for clinicians, and metagenomic next-generation sequencing serves as an important complementary diagnostic tool for individuals with compromised immune systems who may have osteomyelitis, especially when traditional diagnostic methods are uncertain.
