Minireviews
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Sep 18, 2023; 14(9): 662-668
Published online Sep 18, 2023. doi: 10.5312/wjo.v14.i9.662
Silver nanoparticle technology in orthopaedic infections
Madhan Jeyaraman, Naveen Jeyaraman, Arulkumar Nallakumarasamy, Karthikeyan P Iyengar, Vijay Kumar Jain, Anish G Potty, Ashim Gupta
Madhan Jeyaraman, Naveen Jeyaraman, Arulkumar Nallakumarasamy, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600077, Tamil Nadu, India
Madhan Jeyaraman, Anish G Potty, Ashim Gupta, Department of Orthopaedics, South Texas Orthopaedic Research Institute, Laredo, TX 78045, United States
Karthikeyan P Iyengar, Department of Trauma and Orthopaedics, Southport & Ormskirk Hosp NHS Trust Southport, Richmond PR8 6PN, Southport, United Kingdom
Vijay Kumar Jain, Department of Orthopaedics, Atal Bihari Vajpayee Institute of Medical Sciences, Dr Ram Manohar Lohia Hospital, Delhi 110001, New Delhi, India
Ashim Gupta, Department of Regenerative Medicine, Regenerative Orthopaedics, Noida 201301, Uttar Pradesh, India
Ashim Gupta, Department of Regenerative Medicine, Future Biologics, Lawrenceville, GA 30043, United States
Ashim Gupta, Department of Regenerative Medicine, BioIntegarte, Lawrenceville, GA 30043, United States
Author contributions: Jeyaraman M conceptualized the study; Jeyaraman M, Jeyaraman N, Nallakumarasamy A, Iyengar KP and Jain VK contributed to writing, reviewing, and editing the manuscript; Jeyaraman M, Iyengar KP, Potty AG, and Gupta A supervised the study; All authors contributed to the article and approved the submitted version.
Conflict-of-interest statement: All authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Madhan Jeyaraman, MS, PhD, Assistant Professor, Research Associate, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com
Received: April 18, 2023
Peer-review started: April 18, 2023
First decision: July 18, 2023
Revised: July 24, 2023
Accepted: September 4, 2023
Article in press: September 4, 2023
Published online: September 18, 2023
Processing time: 148 Days and 20.5 Hours
Abstract

The irrational and prolonged use of antibiotics in orthopaedic infections poses a major threat to the development of antimicrobial resistance. To combat antimicrobial resistance, researchers have implemented various novel and innovative modalities to curb infections. Nanotechnology involves doping ions/metals onto the scaffolds to reach the target site to eradicate the infective foci. In this connotation, we reviewed silver nanoparticle technology in terms of mechanism of action, clinical applications, toxicity, and regulatory guidelines to treat orthopaedic infections.

Keywords: Antimicrobial resistance, Biofilms, Silver, Nanoparticles, Orthopaedics

Core Tip: To overcome antimicrobial resistance, researchers explored the alternate technology to curb infections in musculoskeletal disorders. Nanotechnology forms an eye opener in the usage of silver nanoparticles to eradicate infections in osteoarticular system.