Clinical Trials Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Jan 18, 2022; 13(1): 78-86
Published online Jan 18, 2022. doi: 10.5312/wjo.v13.i1.78
Can bedside needle arthroscopy of the ankle be an accurate option for intra-articular delivery of injectable agents?
Tobias Stornebrink, Sjoerd A S Stufkens, Nathaniel P Mercer, John G Kennedy, Gino M M J Kerkhoffs
Tobias Stornebrink, Sjoerd A S Stufkens, Gino M M J Kerkhoffs, Department of Orthopedic Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam Movement Sciences, Amsterdam 1105AZ, Netherlands
Tobias Stornebrink, Sjoerd A S Stufkens, Gino M M J Kerkhoffs, Academic Center for Evidence based Sports Medicine, Amsterdam 1105AZ, Netherlands
Tobias Stornebrink, Sjoerd A S Stufkens, Gino M M J Kerkhoffs, Amsterdam Collaboration for Health and Safety in Sports, International Olympic Committee Research Center Amsterdam UMC, Amsterdam 1105AZ, Netherlands
Nathaniel P Mercer, John G Kennedy, Department of Orthopedic Surgery, NYU Langone Health, New York, NY 10010, United States
Author contributions: All authors have made substantial contributions to conception and design of the study, acquisition of data, or analysis and interpretation of data, drafting the article or making critical revisions related to important intellectual content of the manuscript, and final approval of the version of the article to be published.
Supported by Department of Orthopedic Surgery from the Amsterdam UMC was Supported with an Unrestricted Research Grant from Arthrex GmbH.
Institutional review board statement: The study was approved by our institutional ethical review board with reference 2019_203 and conducted in agreement with the 1964 Helsinki Declaration and its later amendments.
Clinical trial registration statement: Prior to the first inclusion, the study was registered at ToetsingOnline.nl with reference NL71185.018.19.
Informed consent statement: All patients provided written consent for their participation in the study prior to enrollment.
Conflict-of-interest statement: Dr. Kennedy reports consultancy fees from Arthrex, outside the submitted work.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gino M M J Kerkhoffs, MD, PhD, Full Professor, Department of Orthopedic Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam Movement Sciences, Meibergdreef 9, Amsterdam 1105AZ, Netherlands. g.m.kerkhoffs@amsterdamumc.nl
Received: May 8, 2021
Peer-review started: May 8, 2021
First decision: October 16, 2021
Revised: November 15, 2021
Accepted: December 31, 2021
Article in press: December 31, 2021
Published online: January 18, 2022
Processing time: 253 Days and 19.1 Hours
Abstract
BACKGROUND

Bedside needle arthroscopy of the ankle under local anesthesia has been proposed for intra-articular delivery of injectable agents. Accuracy and tolerability of this approach in the clinical setting–including patients with end-stage ankle pathology and/or a history of prior surgery–is not known.

AIM

To assess clinical accuracy and tolerability of bedside needle arthroscopy as a delivery system for injectable agents into the tibiotalar joint.

METHODS

This was a prospective study that included adult patients who were scheduled for an injection with hyaluronic acid to the tibiotalar joint. In our center, these injections are used as a last resort prior to extensive surgery. The primary outcome was injection accuracy, which was defined as injecting through the arthroscopic cannula with intra-articular positioning confirmed by a clear arthroscopic view of the joint space. Secondary outcome measures included a patient-reported numeric rating scale (NRS, 0-10) of pain during the procedure and willingness of patients to return for the same procedure. NRS of ankle pain at rest and during walking was collected at baseline and at 2-wk follow-up. Complications were monitored from inclusion up to a 2-wk control visit.

RESULTS

We performed 24 inspection-injections. Eleven (46%) participants were male, and mean age was 46.8 ± 14.5 years. Osteoarthritis was the indication for injection in 20 (83%) cases, of which 8 (33%) patients suffered from osteoarthritis Kellgren-Lawrence grade IV, and 10 (42%) patients from Kellgren-Lawrence grade III. An osteochondral defect was the indication for injection in 4 (17%) cases. A history of ankle surgery was present in 14 (58%) participants and a history of multiple ankle surgeries in 11 (46%) participants. It was possible to confirm accuracy in 21 (88%) procedures. The 3 (12%) participants where needle arthroscopy did not reach a clear view of the joint space all suffered from Kellgren-Lawrence grade IV osteoarthritis. Pain during the procedure was reported with a median of 1 [interquartile ranges (IQR): 0–2]. Willingness to return was 100%. Pain in rest decreased from a median NRS of 4 (IQR: 2–7) at baseline to a median of 3 (IQR: 1–5) at follow-up (P < 0.01). Pain during walking decreased from a median NRS of 8 (IQR: 6–9) to a median of 7 (IQR: 4–8) (P < 0.01). Infections or other complications were not encountered.

CONCLUSION

Clinical accuracy and tolerability of bedside needle arthroscopy of the ankle as a delivery system for injectable agents are excellent. Accuracy was 100% in patients without total ventral joint obliteration.

Keywords: Ankle arthroscopy; NanoScope; Needle arthroscopy; Injections; Proof of concept; Patient experience

Core Tip: Needle arthroscopy is rapidly attracting the interest of the orthopedic field, as recent technical innovation has increased image quality and improved surgical handling. Bedside needle arthroscopy under local anesthesia has been proposed as a possible use. In this study, we performed needle arthroscopic inspection-injections of the tibiotalar joint in the procedure room and using only local anesthesia. We found high accuracy of these guided injections, and excellent patient tolerability of the procedure. The results of this study may form the groundwork for further expansion of indications that merit needle arthroscopy of the ankle under local anesthesia, including operative procedures.