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©2014 Baishideng Publishing Group Inc.
World J Clin Oncol. Aug 10, 2014; 5(3): 311-322
Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.311
Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.311
Table 1 Involvement of epithelial-mesenchymal transition-transcription factors in breast carcinogenesis
EMT-TF | Transcription factor type | Deregulated in breast cancer | Association with biological and clinico-pathological features in breast cancer |
SNAI1 (Snail) | Zinc finger | High levels[75] | Lymph node metastasis, effusion, distant metastasis, recurrence |
SNAI2 (Slug) | Zinc finger | High levels[76] | Effusion, distant metastasis, recurrence, stemness capacities |
TWIST1 | Basic Helix-loop-Helix | Up-regulated[77] | Primary transformation, escape from failsafe programs, invasion, bone metastasis, angiogenesis, poor prognosis |
ZEB1 | Zinc finger E-box-binding homeobox 1 | High levels[76,77] | Invasion, distant metastasis |
ZEB2 | Zinc finger E-box-binding homeobox 2 | High levels[76,77] | Invasion, distant metastasis, stemness capacities |
FoxC2 | Forkhead-related protein FKHL14, FKH-14, mesenchyme fork head protein 1 | High levels[78] | Stemness capacities, distant metastasis |
Oct3/4 | Octamer-binding transcription factor 4, POU domain, class 5, transcription factor 1S homeodomain transcription factor of the POU family | Up-regulated[79] | Stemness capacities, invasion, migration |
Sox2 | Sex determining region Y-box 2 highly conserved DNA binding domains High-mobility group box domains | Up-regulated[80] | Tamoxifen-resistance, lymph node metastasis, stemness capacities |
Prrx1 | Paired related homeobox 1 | High levels[15] | Metastasis, poor prognosis |
TCF4 | Basic Helix-loop-Helix immunoglobulin transcription factor 2 | Up-regulated[81,82] | Metastasis, poorer prognosis in patients with high levels of osteopontin and better prognosis with low levels of osteopontin |
- Citation: Moyret-Lalle C, Ruiz E, Puisieux A. Epithelial-mesenchymal transition transcription factors and miRNAs: “Plastic surgeons” of breast cancer. World J Clin Oncol 2014; 5(3): 311-322
- URL: https://www.wjgnet.com/2218-4333/full/v5/i3/311.htm
- DOI: https://dx.doi.org/10.5306/wjco.v5.i3.311