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World J Clin Oncol. Aug 10, 2014; 5(3): 311-322
Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.311
Epithelial-mesenchymal transition transcription factors and miRNAs: “Plastic surgeons” of breast cancer
Caroline Moyret-Lalle, Emmanuelle Ruiz, Alain Puisieux
Caroline Moyret-Lalle, Emmanuelle Ruiz, Alain Puisieux, INSERM UMR-S1052, Centre de Recherche en Cancérologie de Lyon, 69008 Lyon, France
Caroline Moyret-Lalle, Emmanuelle Ruiz, Alain Puisieux, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008 Lyon, France
Caroline Moyret-Lalle, Emmanuelle Ruiz, Alain Puisieux, Laboratoire d’EXcellence DEVweCAN, INSERM UMR-S1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008 Lyon, France
Caroline Moyret-Lalle, Emmanuelle Ruiz, Alain Puisieux, INSERM UMR-S1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, 69008 Lyon, France
Author contributions: Moyret-Lalle C and Ruiz E wrote the manuscript and designed the figures; Puisieux A coordinated and was involved in editing the manuscript.
Supported by The Ligue Nationale contre le Cancer, to Puisieux A
Correspondence to: Caroline Moyret-Lalle, PhD, Laboratoire d’EXcellence DEVweCAN, INSERM UMR-S1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 43 Boulevard du 11 Novembre 1918, 69008 Lyon, France. caroline.moyret-lalle@lyon.unicancer.fr
Telephone: +33-4-78782710 Fax: +33-4-78782020
Received: January 3, 2014
Revised: June 13, 2014
Accepted: June 27, 2014
Published online: August 10, 2014
Processing time: 209 Days and 17 Hours
Core Tip

Core tip: Epithelial-mesenchymal transition (EMT) and the reverse mesenchymal-epithelial transition (MET) are both involved in breast cancer plasticity. Embryonic transcription factors and miRNAs are key players regulating the balance between these two processes allowing cells that underwent EMT to transiently re-acquire epithelial phenotype. Here we highlighted the complex transcription factors/miRNAs regulation networks involved in EMT-MET during breast cancer progression and the central role played by Dicer, the key enzyme of miRNAs processing, in EMT process. These key regulators of EMT-MET may represent predictive markers and potential therapeutic targets for breast cancers.