Targeted maintenance therapy for a young woman with cervical rhabdomyosarcoma: A case report and review of literature

Table 1 Retrospective studies

Ref.	Design, n	ID	Age	Side	Stage	Surgery	Chemotherapy	Radiotherapy	Recurrence	Vital status (months)
Montag et al[12], 1986	Retrospective n = 6	1	22	Uterine	Unkonwn	Radical hysterectomy and bilateral pelvic lymphadenectomy were performed	VAC	No	No	156/NED
		2	42	Uterine	Unkonwn	Abdominal hysterectomy, bilateral salpingo-oophorectomy, omental biopsy, and pelvic and paraaortic lymph node biopsies were performed	VAC	No	No	120/NED
		3	21	Uterine	Unkonwn	Radical hysterectomy, bilateral pelvic lymphadenectomy, and incidental appendectomy	VAC (16 course)	Yes	Recurrence 9 months after surgery	96/NED
		4	23	Uterine	Unkonwn	Underwent modified radical hysterectomy, bilateral salpingo-oophorectomy, and bilateral pelvic lymphadenectomy	Doxorubicin	Yes	No	24/NED
		5	11	Cervix	Unkonwn	Underwent radical hysterectomy and bilateral pelvic lymphadenectomy	VAC	No	No	84/NED
		6	26	Cervix	Unkonwn	Underwent radical hysterectomy, bilateral pelvic lymphadenectomy, and paraaortic node sampling	VAC (6 course)	No	No	17/NED
Ghaemmaghamiet al[13], 2008	Retrospective n = 6	1	15	Vagina	II	Wide local excision	VAC	No	No	60/NED
		2	13	Vagina	I	Local excision	VAC	No	No	54/NED
		3	16	Vagina	I	Local excision	VAC	No	No	10/NED
		4	15	Cervix	Ⅲ	RH/BOS/LND	Ifosfamide	Yes	Yes	9/NED
		5	21	Cervix	IB2	Wide local excision/trachelectomy	VAC	No	Yes	6/NED
		6	30	Cervix	IB2	Conization	VAC	No	No	8/NED
Kriseman et al[14], 2012	Retrospective n = 11	1	17	Cervix	IB1	Conization	VAC	No	No	23/NED
		2	12	Cervix	IB2	Conization	VAC	No	No	6/NED
		3	33	Cervix	IB1	TAH and BSO	Cisplatin and doxorubicin	Yes	Yes	Dead of complications related to neutropenic fever
		4	49	Cervix	IB1	TAH and BSO	Cyclophosphamide,doxorubicin,vincristine, and anddacarbazine	Yes	No	Dead of parotid adenocarcinoma
		5	51	Cervix	IB2	Conization	No	No	No	19/NED
		6	2	Cervix	IIA	Polypectomy	VAC	No	No	35/NED
		7	12	Uterine	IB2	TAH	VAC	No	No	121/NED
		8	17	Cervix	Unkonwn	Conization	Vincristine,doxorubicin, and cyclophosphamide	No	No	Dead of disease
		9	34	Cervix	Unkonwn	Conization	VAC, FAC	No	Unkonwn	Dead of unknown cause
		10	27	Cervix	IB2	Conization	No	No	Unkonwn	Alive with disease
		11	18	Cervix	IB1	Conization	VAC	No	No	4/NED
Narin et al[15], 2016	Retrospective n = 5	1	16	Cervix	I	Polypectomy	VAC	No	No	102/NED
		2	11	Cervix	I	Polypectomy	VAC	No	Yes	57/NED
		3	23	Cervix	I	Radical hysterectomy	VAC + cisplatin	Yes	Yes	22/NED
		4	14	Cervix	I	Polypectomy	VAC	No	No	37/NED
		5	15	Cervix	I	Polypectomy	VAC	No	No	15/NED

FAC: Fluorouracil, doxorubicin, and cyclophosphamide; VAC: Vincristine, actinomycin D, and cyclophosphamide; NED: No evidence of disease; RH: Radical hysterectomy; BSO: Bilateral salpingo-oophorectomy; LND: Lymph node dissection; TAH: Total abdominal hysterectomy.

Table 2 Case reports

Ref.	Design, n	Age	Side	Stage	Surgery	Chemotherapy	Radiotherapy	Recurrence	Vital status (months)
Gruessner et al[16], 2004	Case report	5	Cervix	IA	Polypectomy	VAC	No	No	39/NED
Scaravilli et al[17], 2009	Case report	35	Cervix	I1	Total laparohysterectomy with bilateral annessiectomy and pelvic lymphadenectomy	Cysplatinum, adriamycin and dacarbazin + vincristine and actinomycin	No	No	12+/NED
Koukourakis et al[18], 2009	Case report	20	Cervix	IIA	Radical hysterectomy, upper vaginectomy and bilateral pelvic lymphadenectomy were performed	Ifosfamide + etoposide + cisplatin	Yes	No	3/NED
Ocheke et al[19], 2011	Case report	16	Cervix	Unkonwn	Polypectomy	No	No	Yes	6/Died
Karaman et al[20], 2011	Case report	22	Cervix	IA	Conization	VAC	No	No	18/NED
Melo et al[21], 2012	Case report	20	Cervix	IA	Radical surgery	Ifosfamide vincristine actinomycin	No	No	36/NED
Xu et al[22], 2022	Case report	39	Cervix	IB3	Laparoscopic radical hysterectomy, bilateral salpingo-oophrectomy and pelvic lymph node dissection	VAC	No	No	49/NED
Pop et al[7], 2023	Case report	46	Cervix	IA1	C1-type hysterectomy	vincristine ifosfamide doxorubicin etoposide and CHT	Yes	Yes	60/NED

VAC: Vincristine, actinomycin D, and cyclophosphamide; NED: No evidence of disease; CHT: Chemotherapy.