Ma HR, Zhang D, Li L, Qi L, Wang L, Li YT, Wang YR. Targeted maintenance therapy for a young woman with cervical rhabdomyosarcoma: A case report and review of literature. World J Clin Oncol 2025; 16(3): 101909 [DOI: 10.5306/wjco.v16.i3.101909]
Corresponding Author of This Article
Li Li, Department of Gynecologic Oncology, Affiliated Hospital of Qinghai University, No. 29 Tongren Road, Chengxi District, Xining 810000, Qinghai Province, China. 1215014711@qq.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Mar 24, 2025; 16(3): 101909 Published online Mar 24, 2025. doi: 10.5306/wjco.v16.i3.101909
Targeted maintenance therapy for a young woman with cervical rhabdomyosarcoma: A case report and review of literature
Huan-Ran Ma, Dan Zhang, Li Li, Lin Qi, Liang Wang, Yi-Tong Li, Ya-Ru Wang
Huan-Ran Ma, Dan Zhang, Li Li, Lin Qi, Yi-Tong Li, Ya-Ru Wang, Department of Gynecologic Oncology, Affiliated Hospital of Qinghai University, Xining 810000, Qinghai Province, China
Liang Wang, Department of Gastrointestinal Oncology Surgery, Affiliated Hospital of Qinghai University, Xining 810000, Qinghai Province, China
Co-first authors: Huan-Ran Ma and Dan Zhang.
Author contributions: Ma HR and Zhang D co-worked on the manuscript and reviewed the literature, they contributed equally to this article, they are the co-first authors of this manuscript; Li L contributed to the article concept and design and revised and reviewed the manuscript; Qi L provides image data for this manuscript; Wang L provides help for polishing and submitting this manuscript; Li YT and Wang YR participated in the tabulation of this manuscript; and all authors have read and approved the final manuscript.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li Li, Department of Gynecologic Oncology, Affiliated Hospital of Qinghai University, No. 29 Tongren Road, Chengxi District, Xining 810000, Qinghai Province, China. 1215014711@qq.com
Received: September 30, 2024 Revised: November 19, 2024 Accepted: December 5, 2024 Published online: March 24, 2025 Processing time: 112 Days and 21.6 Hours
Abstract
BACKGROUND
Rhabdomyosarcoma of the uterine cervix is a rare form of soft-tissue sarcoma predominantly affecting young women, with no established standard treatment protocol.
CASE SUMMARY
This report presents a case of a 17-year-old female patient presenting with intermittent, non-cyclical vaginal bleeding and associated lower abdominal pain. Pelvic magnetic resonance imaging and additional examinations led to the diagnosis of cervical rhabdomyosarcoma. The primary treatment options for uterine cervical rhabdomyosarcoma include surgery, with or without adjuvant chemotherapy and radiotherapy. This patient underwent surgery followed by a postoperative chemotherapy regimen of gemcitabine combined with docetaxel and bevacizumab. After 19 months of follow-up, the patient showed no signs of recurrence and maintained good overall health. Given the rarity of cervix rhabdomyosarcoma, this case is presented to provide insights into the diagnosis and treatment of this condition.
CONCLUSION
This suggests that bevacizumab may demonstrate potential efficacy in the treatment of cervical rhabdomyosarcoma. In the future, targeted therapy is expected to play an increasingly significant role in the management of rhabdomyosarcoma.
Core Tip: Rhabdomyosarcoma sarcoma is a malignant tumor originating from rhabdomyocytes or mesenchymal cells that differentiate toward rhabdomyocytes and is the most common type of soft-tissue sarcoma in children. This paper reports a case of a young female patient with cervical rhabdomyosarcoma who underwent radical surgery, followed by chemotherapy and targeted maintenance therapy, resulting in a favorable prognosis. Given the rarity of this case, we review previous literature and provide new insights into the diagnosis, treatment, and prognosis of uterine cervical rhabdomyosarcoma.
