Elevated cardiovascular risk and acute events in hospitalized colon cancer survivors: A decade-apart study of two nationwide cohorts

Table 1 Demographics and comorbidities of hospitalizations among colon cancer survivors a decade apart: Propensity matched analysis

Variable	2007 (n = 177542)	2017 (n = 178325)	P value
Age (yr) at admission, median (IQR)	77 (67-84)	76 (65-84)	< 0.001
Sex, n (%)
Male	86792 (48.9)	89485 (50.2)	< 0.001
Female	90750 (51.1)	88840 (49.8)
Race
White	142763 (80.4)	132770 (74.5)	< 0.001
Black	16975 (9.6)	21750 (12.2)
Hispanic	9506 (5.4)	13045 (7.3)
Asian or Pacific Islander	3962 (2.2)	5140 (2.9)
Native American	836 (0.5)	830 (0.5)
Others	3499 (2.0)	4790 (2.7)
Median household income quartile, n (%)			< 0.001
0th-25th	45378 (25.6)	47100 (26.4)
76th-100th	44838 (25.3)	41700 (23.4)
Urban teaching facility, n (%)	90450 (50.9)	94790 (53.2)	< 0.001
Non-elective admission, n (%)	136359 (76.9)	147545 (82.9)	< 0.001
Comorbidities, n (%)
Alcohol abuse	3069 (1.7)	3835 (2.2)	< 0.001
Congestive heart failure	18256 (10.3)	25510 (14.3)	< 0.001
Coagulopathy	5738 (3.2)	11535 (6.5)	< 0.001
Hypertension	109779 (61.8)	131870 (73.9)	< 0.001
Hyperlipidemia	46873 (26.4)	77505 (43.5)	< 0.001
Diabetes	44331 (25.0)	52910 (29.7)	< 0.001
Smoking	31260 (17.6)	72955 (40.9)	< 0.001
Obesity	8031 (4.5)	19750 (11.1)	< 0.001
At least 1 Traditional CVD risk factor	138285 (77.9)	159640 (89.5)	< 0.001
Peripheral vascular diseases	11370 (6.4)	11890 (6.7)	0.001
Renal failure	19316 (10.9)	35075 (19.7)	< 0.001
Liver disease	3369 (1.9)	6760 (3.8)	< 0.001
Weight loss	5993 (3.4)	15405 (8.6)	< 0.001
Drug abuse	1165 (0.7)	2650 (1.5)	< 0.001

IQR: Interquartile range; CVD: Cardiovascular disease.

Table 2 Hospitalization outcomes among colon cancer survivors a decade apart: Propensity matched analysis

Variable	2007 (n = 177542)	2017 (n = 178325)	OR	CI (UL-LL)	Adjusted P value
All-cause mortality	5245 (3.0)	5165 (2.9)	0.32	0.99 (0.95-1.04)	0.77
Pulmonary embolism	2290 (1.3)	2470 (1.4)	0.013	1.47 (1.37-1.58)	< 0.001
Arrhythmia	41948 (23.6)	54595 (30.6)	< 0.001	1.41 (1.38-1.43)	< 0.001
Atrial fibrillation/flutter	31280 (17.6)	44875 (25.2)	< 0.001	1.61 (1.58-1.64)	< 0.001
Cardiac arrest including ventricular tachyarrhythmias	609 (0.3)	1065 (0.6)	< 0.001	1.63 (1.46-1.82)	< 0.001
Stroke	4409 (2.5)	5675 (3.2)	< 0.001	1.28 (1.22-1.34)	< 0.001
Routine discharge	97712 (55.0)	86785 (48.7)	< 0.001

Multivariable analysis was adjusted for demographics, hospital characteristics and all relevant comorbidities. IQR: Interquartile range; CVD: Cardiovascular disease.