New trends in the surgical management of soft tissue sarcoma: The role of preoperative biopsy

Table 1 Federation of the French Cancer Centres histological grading criteria

Differentiation (score)	Necrosis (score)	Mitotic count (score)
Well (1)	Absent (0)	n < 101 (1)
Moderate (2)	< 50% (1)	n = 10–191 (2)
Poor (anaplastic) (3)	≥ 50% (2)	n ≥ 201 (3)

¹Number of mitoses per 10 high power fields.

After summing the three scores, grade 1 is defined as a total score of 2 or 3; grade 2 as a total score of 4 or 5; and grade 3 as a total score of 6 to 8.

Table 2 American Joint Committee on Cancer classification and staging for soft tissue sarcoma, 8^th Edition

TNM classification	Stage
T1: Tumor ≤ 5 cm	IA: T1; N0; M0; G1
T2: Tumor > 5 cm and ≤ 10 cm	IB: T2, T3, T4; N0; M0; G1
T3: Tumor > 10 cm and ≤ 15 cm	II: T1; N0; M0; G2/3
T4: Tumor > 15 cm	IIIA: T2; N0; M0; G2/3
N0: No regional lymph node metastasis or unknown lymph node status	IIIB: T3, T4; N0; M0; G2/3
N1: Regional lymph node metastasis	IV: Any T; N1; M0; any G Any T; any N; M1; any G
M0: No distant metastasis
M1: Distant metastasis

G expresses the histological grading sum score. TNM: Tumor-Node-Metastasis.