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©The Author(s) 2020.
World J Clin Oncol. Feb 24, 2020; 11(2): 74-82
Published online Feb 24, 2020. doi: 10.5306/wjco.v11.i2.74
Published online Feb 24, 2020. doi: 10.5306/wjco.v11.i2.74
Ref. | Topic | Patients | (Prevalent) Histological subtype(s) | Chemotherapy/ radiotherapy | Outcome (after diagnosis of metastasis) | |
Total number of STS (n), of whom eSTS, n (%) | Of whom eSTS with AM/RM, n (%) | |||||
Thompson et al[16], 2015 | Diagnostic pathway | 140 (100) | 7 (5.0) AM | Epithelioid sarcoma, leiomyosarcoma, liposarcoma, synovial sarcoma | N/A | N/A |
King et al[9], 2009 | Diagnostic pathway, outcome | 124 (100) | 7 (5.6) AM | MPNST, leiomyosarcoma, myxofibrosarcoma, pleomorphic sarcoma | N/A | 21% mortality rate (n = 21/124) |
Gorelik et al[6], 2018 | Diagnostic pathway | 33 (100) | 4 (12.1) AM | Myxoid liposarcoma | 89% of patients with metastases (including others than AM) received neoadj. RTX 22% received adj. RTX for primary tumour | N/A |
Behranwala et al[8], 2004 | Therapeutic approach | 2127 (100) | 19 (0.9) AM | Myxoid liposarcoma, leiomyosarcoma | CTX + RTX in 3 patients, and CTX or RTX in 1 patient each following resection of AM | Median OS: 12 mo |
Ogose et al[11], 2000 | Therapeutic approach | 282 (100) | 24 (8.5) AM | Liposarcoma | None of patients with AM received RTX or CTX | Mean OS (liver/GI metastases): 4.6 mo; Mean OS (pancreatic metastasis): 3.3 mo |
Sheah et al[7], 2008 | Diagnostic pathway | 112 (100) | 9 (8.0) AM; 2 (1.8) RM | Myxoid liposarcoma | N/A | N/A |
Ref. | Type | Topic | Patients | (Prevalent) Histological subtype(s) | Chemotherapy/ radiotherapy | Outcome (after diagnosis of metastasis) |
Grimme et al[15], 2019 | Original article | Therapeutic approach, outcome | 38 patients with STS developing liver metastases [of whom 5 (13.2%) had been eSTS] | Leiomyosarcoma, liposarcoma | N/A | Median PFS: 16 mo Median OS: 46 mo |
Lev-Chelouche et al[14], 2000 | Original article | Diagnostic pathway, therapeutic approach | 10 eSTS patients with RM | Liposarcoma | Adj. CTX in 4 patients, ± adj. RTX in 7 (details on combination of CTX/RTX not provided) | Mean OS: 13.3 mo |
Rehders et al[23], 2009 | Original article | Therapeutic approach | 5 patients with eSTS (of 45 patients with STS) developing liver metastases | N/A | CTX following hepatic metastasectomy in 5 patients (no information whether eSTS or other STS) | 44 mo (including both eSTS and other STS) |
Sabel et al[19], 2001 | Case report | N/A | 58-yr-old male patient with small-bowel metastasis after 15 yr of follow-up | Alveolar soft part sarcoma | Adj. RTX for primary tumour, CTX for metastases (prior to development of AM) | N/A |
Lee et al[18], 2010 | Case report | N/A | 23-yr-old male patient with gastric metastasis at 16 mo of follow-up | Alveolar soft part sarcoma | RTX for cerebral metastases, CTX declined by patient | DOD soon after metastasectomy (not specified by authors) |
Koh et al[21], 2007 | Case report | N/A | 66-yr-old female with pancreatic metastasis soon after primary tumour diagnosis | Malignant mesenchymoma (70% osteosarcoma, 30% leiomyosarcoma) | CTX and RTX declined by patient | AWD at 9 mo |
Mizoshiri et al[17], 2018 | Case report | N/A | 51-yr-old female with liver metastasis from leiomyosarcoma at 11 mo of follow-up | Leiomyosarcoma | Neoadj. + adj. CTX for primary tumour and CTX following hepatic metastasectomy in female patient | NED at 12 mo (male patient) |
60-yr-old male with liver metastasis from leiomyosarcoma at 3 yr of follow-up | Neoadj. + adj. CTX for male patient for primary tumour | |||||
Carboni et al[13], 2006 | Case report | N/A | 66-yr-old male patient with pancreatic metastasis at 6 yr of follow-up | Myxoid liposarcoma | Adjuvant RTX for local recurrence of primary tumour | NED at 6 mo |
Watanabe et al[12], 2001 | Case report | N/A | 20-yr-old female patient with massive AM (37 cm diameter) | Myxoid liposarcoma | N/A | DOD (after several months, not specified by authors) |
Lin et al[10], 2015 | Case report | N/A | 53-yr-old male patient with AM after 35 mo of follow-up | Myxoid liposarcoma | CTX and RTX for metastatic disease (prior to development of AM) | DOD after 3 mo |
Willekens et al[20], 2011 | Case report | N/A | 27-yr-old female patient with duodenal metastasis | Alveolar soft part sarcoma | RTX for primary tumour | NED at 2 mo |
- Citation: Smolle MA, Leithner A, Bernhardt GA. Abdominal metastases of primary extremity soft tissue sarcoma: A systematic review. World J Clin Oncol 2020; 11(2): 74-82
- URL: https://www.wjgnet.com/2218-4333/full/v11/i2/74.htm
- DOI: https://dx.doi.org/10.5306/wjco.v11.i2.74