Systematic Review
Copyright ©The Author(s) 2020.
World J Clin Oncol. Feb 24, 2020; 11(2): 74-82
Published online Feb 24, 2020. doi: 10.5306/wjco.v11.i2.74
Table 1 Original articles (n = 6) analysing incidence of abdominal/retroperitoneal metastases in patients with extremity soft tissue sarcoma
Ref.TopicPatients
(Prevalent) Histological subtype(s)Chemotherapy/ radiotherapyOutcome (after diagnosis of metastasis)
Total number of STS (n), of whom eSTS, n (%)Of whom eSTS with AM/RM, n (%)
Thompson et al[16], 2015Diagnostic pathway140 (100)7 (5.0) AMEpithelioid sarcoma, leiomyosarcoma, liposarcoma, synovial sarcomaN/AN/A
King et al[9], 2009Diagnostic pathway, outcome124 (100)7 (5.6) AMMPNST, leiomyosarcoma, myxofibrosarcoma, pleomorphic sarcomaN/A21% mortality rate (n = 21/124)
Gorelik et al[6], 2018Diagnostic pathway33 (100)4 (12.1) AMMyxoid liposarcoma89% of patients with metastases (including others than AM) received neoadj. RTX 22% received adj. RTX for primary tumourN/A
Behranwala et al[8], 2004Therapeutic approach2127 (100)19 (0.9) AMMyxoid liposarcoma, leiomyosarcomaCTX + RTX in 3 patients, and CTX or RTX in 1 patient each following resection of AMMedian OS: 12 mo
Ogose et al[11], 2000Therapeutic approach282 (100)24 (8.5) AMLiposarcomaNone of patients with AM received RTX or CTXMean OS (liver/GI metastases): 4.6 mo; Mean OS (pancreatic metastasis): 3.3 mo
Sheah et al[7], 2008Diagnostic pathway112 (100)9 (8.0) AM; 2 (1.8) RMMyxoid liposarcomaN/AN/A
Table 2 Original articles (n = 3) and case reports (n = 8) exclusively reporting on patients developing abdominal or retroperitoneal metastases
Ref.TypeTopicPatients(Prevalent) Histological subtype(s)Chemotherapy/ radiotherapyOutcome (after diagnosis of metastasis)
Grimme et al[15], 2019Original articleTherapeutic approach, outcome38 patients with STS developing liver metastases [of whom 5 (13.2%) had been eSTS]Leiomyosarcoma, liposarcomaN/AMedian PFS: 16 mo Median OS: 46 mo
Lev-Chelouche et al[14], 2000Original articleDiagnostic pathway, therapeutic approach10 eSTS patients with RMLiposarcomaAdj. CTX in 4 patients, ± adj. RTX in 7 (details on combination of CTX/RTX not provided)Mean OS: 13.3 mo
Rehders et al[23], 2009Original articleTherapeutic approach5 patients with eSTS (of 45 patients with STS) developing liver metastasesN/ACTX following hepatic metastasectomy in 5 patients (no information whether eSTS or other STS)44 mo (including both eSTS and other STS)
Sabel et al[19], 2001Case reportN/A58-yr-old male patient with small-bowel metastasis after 15 yr of follow-upAlveolar soft part sarcomaAdj. RTX for primary tumour, CTX for metastases (prior to development of AM)N/A
Lee et al[18], 2010Case reportN/A23-yr-old male patient with gastric metastasis at 16 mo of follow-upAlveolar soft part sarcomaRTX for cerebral metastases, CTX declined by patientDOD soon after metastasectomy (not specified by authors)
Koh et al[21], 2007Case reportN/A66-yr-old female with pancreatic metastasis soon after primary tumour diagnosisMalignant mesenchymoma (70% osteosarcoma, 30% leiomyosarcoma)CTX and RTX declined by patientAWD at 9 mo
Mizoshiri et al[17], 2018Case reportN/A51-yr-old female with liver metastasis from leiomyosarcoma at 11 mo of follow-upLeiomyosarcomaNeoadj. + adj. CTX for primary tumour and CTX following hepatic metastasectomy in female patientNED at 12 mo (male patient)
60-yr-old male with liver metastasis from leiomyosarcoma at 3 yr of follow-upNeoadj. + adj. CTX for male patient for primary tumour
Carboni et al[13], 2006Case reportN/A66-yr-old male patient with pancreatic metastasis at 6 yr of follow-upMyxoid liposarcomaAdjuvant RTX for local recurrence of primary tumourNED at 6 mo
Watanabe et al[12], 2001Case reportN/A20-yr-old female patient with massive AM (37 cm diameter)Myxoid liposarcomaN/ADOD (after several months, not specified by authors)
Lin et al[10], 2015Case reportN/A53-yr-old male patient with AM after 35 mo of follow-upMyxoid liposarcomaCTX and RTX for metastatic disease (prior to development of AM)DOD after 3 mo
Willekens et al[20], 2011Case reportN/A27-yr-old female patient with duodenal metastasisAlveolar soft part sarcomaRTX for primary tumourNED at 2 mo