Liposarcoma of the breast arising in a malignant phyllodes tumor: A case report and review of the literature

Figure 1 Mammography of the right breast shows a round lesion with smooth margins measuring 2. 6 cm in the lower inner quadrant (A and B).

Figure 2 Breast ultrasound shows an irregular structure of complex echogenicity measuring 2. 4 cm × 2.0 cm × 1.6 cm (BI-RADS 5) (A and B).

Figure 3 Lumpectomy; histopathological workup described a malignant phyllodes tumor of 21 mm diameter with a specific heterologous component identified as well differentiated liposarcoma. A: Breast excision with centrally located phyllodes tumor (zoom × 3); B: Atypical stroma component of the phyllodes tumor including lipoblasts with multiple vacuoles (× 400); C: Intraductal phyllodes tumor with typical architecture harboring the liposarcomatous component (× 27); D: Hypercellular stroma of the phyllodes tumor showing striking atypia (left) and multivacuolated atypical lipoid cells (right) (× 200).