IL-6/IL-6R as a potential key signaling pathway in prostate cancer development

Figure 1 Schematic of IL-6 classical and trans-signaling pathway. IL-6: Interleukin 6; JAK: Janus kinase; MAPK: Mitogen-activated protein kinase; PI3K; Phosphatidylinositol 3-kinase; RANKL: Receptor activator of nuclear factor κB ligand; sIL-6R: Soluble IL-6 receptor; STAT3: Signal transducer and activator of transcription 3.

Figure 2 Hypothetical representation of AR pathway regulation by IL-6 in prostate cancer cells. IL-6: Interleukin 6; MAPK: Mitogen-activated protein kinase; STAT3: Signal transducer and activator of transcription 3; AR: Androgen receptor; PSA: Prostate-specific antigen.