Deciphering prognostic markers in gastric signet ring cell carcinoma: Human epidermal growth factor receptor 2 and other key factors

Figure 1 Survival curve (disease-free survival) in relation to tumor surgical margin. 0 indicates negative margin, and 1 indicates positive margin.

Figure 2 Histopathological and immunohistochemical features of gastric signet ring cell carcinoma. A and B: Gastric signet ring cell carcinoma (SRCC) infiltrating the gastric muscularis mucosa (original magnification: × 200); C: SRCC present within a lymphovascular embolus (original magnification: × 400); D: Human epidermal growth factor receptor 2-stained gastric SRCC, positive score 3+, (original magnification: × 400).

Figure 3 Overall survival curves. Stratified by sex tumor-node-metastasis stage, CA 19-9, CEA. CA 19-9: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen.

Figure 4 The T stage of the tumor. A and B: Gastric signet ring cell carcinoma (SRCC) infiltrating the gastric mucosa; C: SRCC of the cardia extending into the adjacent esophagus; D: SRCC involving the gastric submucosa. A, C and D original magnification: × 400, B original magnification: × 200.