Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Aug 24, 2025; 16(8): 107987
Published online Aug 24, 2025. doi: 10.5306/wjco.v16.i8.107987
Deciphering prognostic markers in gastric signet ring cell carcinoma: Human epidermal growth factor receptor 2 and other key factors
Noura Atef A Ebrahim, Moamen O Othman, Neveen S Tahoun, Rasha A Salama, Aya Arafat, Nancy H Amin
Noura Atef A Ebrahim, Neveen S Tahoun, Nancy H Amin, Department of Oncologic Pathology, National Cancer Institute, Cairo University, Cairo 11796, Egypt
Moamen O Othman, Kasr Al-Aini Faculty of Medicine, Cairo University, Cairo 11562, Egypt
Rasha A Salama, Department of Community Medicine, Ras Al Khaimah Medical and Health Science University, Ras Al Khaimah 11172, United Arab Emirates
Aya Arafat, Department of Clinical and Chemical Pathology, Kasr Al-Aini faculty of Medicine, Cairo University, Cairo 11562, Egypt
Author contributions: Ebrahim NAA designed the study, conducted histopathological and immunohistochemical examinations,was responsible for data collection and data interpretation, and drafted the manuscript; Othman MO assisted in data collection; Tahoun NS provided valuable guidance and reviewed the manuscript; Salama RA and Arafat A offered clinical insights; Othman MO, Arafat A, and Salama RA contributed to the manuscript revisions; Amin NH supported the histological examinations and contributed to the immunohistochemistry analysis; Salama RA, Arafat A, and Amin NH contributed to data interpretation; all authors approved the final version to publish.
Institutional review board statement: This study is approved by Cairo University National Cancer Institute Institutional Review Board, No. PA2502-501-092-196.
Informed consent statement: Due to the retrospective nature of the study, Cairo University National Cancer Institute Institutional Review Board waived the need of obtaining informed consent.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Data sharing statement: The data that support the findings of this study are not openly available due to reasons of sensitivity and are available from the corresponding author upon reasonable request at npathologist@gmail.com.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Noura Atef A Ebrahim, MD, PhD, Postdoc, Assistant Professor, Consultant, Post Doctoral Researcher, Department of Oncologic Pathology, National Cancer Institute, Cairo University, Fom El-Khalig Street, Cairo 11796, Egypt. npathologist@gmail.com
Received: April 2, 2025
Revised: April 29, 2025
Accepted: June 18, 2025
Published online: August 24, 2025
Processing time: 140 Days and 15.8 Hours
Core Tip

Core Tip: This study provided a comprehensive analysis of gastric signet ring cell carcinoma, emphasizing its unique histopathological features, clinical implications, and prognostic significance. By examining key tumor characteristics, including infiltration patterns and molecular alterations, the research highlighted the challenges in early diagnosis and treatment. The findings contributed to a deeper understanding of the aggressive nature of signet ring cell carcinoma and its impact on patient outcomes, underscoring the need for improved diagnostic strategies and targeted therapeutic approaches.