Review
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Sep 14, 2018; 9(5): 83-89
Published online Sep 14, 2018. doi: 10.5306/wjco.v9.i5.83
Role of polymorphisms in genes that encode cytokines and Helicobacter pylori virulence factors in gastric carcinogenesis
Breno Bittencourt de Brito, Filipe Antônio França da Silva, Fabrício Freire de Melo
Breno Bittencourt de Brito, Filipe Antônio França da Silva, Fabrício Freire de Melo, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029-094, Brazil
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Fabrício Freire de Melo, PhD, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58, Quadra 17, Lote 58, Vitória da Conquista 45029-094, Brazil. freiremelo@yahoo.com.br
Telephone: +55-77-991968134
Received: April 30, 2018
Peer-review started: April 30, 2018
First decision: May 17, 2018
Revised: June 23, 2018
Accepted: June 27, 2018
Article in press: June 28, 2018
Published online: September 14, 2018
Processing time: 138 Days and 14.9 Hours
Core Tip

Core tip: Various polymorphisms in host genes that encode cytokines and Helicobacter pylori virulence factors have been associated with different tendencies of gastric diseases development. Several reviews have been written on the role of host and bacterial isolated factors in gastric carcinogenesis. However, only a small amount of reviews unites the important characteristics of both bacterium and host in carcinogenesis. General overviews about polymorphisms in genes that encode cytokines are also scarce. We aimed to join the main polymorphisms in genes that encode cytokines and bacterial virulent factors related to gastric carcinogenesis and to provide a broad overview about these themes.