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World J Clin Oncol. Aug 13, 2018; 9(4): 60-70
Published online Aug 13, 2018. doi: 10.5306/wjco.v9.i4.60
Polyubiquitination inhibition of estrogen receptor alpha and its implications in breast cancer
Angeles C Tecalco-Cruz, Josué O Ramírez-Jarquín
Angeles C Tecalco-Cruz, Programa de Investigación de Cáncer de Mama (PICM), Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México 04510, México
Josué O Ramírez-Jarquín, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México 04510, México
Author contributions: Tecalco-Cruz AC participated in the research, organization of this article and wrote the manuscript; Ramírez-Jarquín JO participated in the research, and improvement of this article and all figures of this article.
Supported by the DGAPA-UNAM, Nos. PAPIIT-IA200916 and PAPIIT-IA201618.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Angeles C Tecalco-Cruz, PhD, Full Professor, Programa de Investigación de Cáncer de Mama (PICM), Departamento de Biología Moleculary Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, México 04510, México. 12anget@gmail.com
Telephone: +52-55-56229208
Received: April 27, 2018
Peer-review started: April 27, 2018
First decision: June 15, 2018
Revised: June 22, 2018
Accepted: June 28, 2018
Article in press: June 29, 2018
Published online: August 13, 2018
Processing time: 108 Days and 6.9 Hours
Core Tip

Core tip: The inhibition of the estrogen receptor alpha polyubiquitination and degradation by several molecular mechanisms is related to the progression of breast cancer and resistance to endocrine therapy.