Al-Sharif E, Simoneau E, Hassanain M. Portal vein embolization effect on colorectal cancer liver metastasis progression: Lessons learned. World J Clin Oncol 2015; 6(5): 142-146 [PMID: 26468450 DOI: 10.5306/wjco.v6.i5.142]
Corresponding Author of This Article
Dr. Mazen Hassanain, Associate Professor of Surgery and Consultant Hepatobiliary and Transplant Surgery, Department of Surgery, College of Medicine, Scientific Director Liver Disease Research Centre, King Saud University, PO Box 25179, Riyadh 11466, Saudi Arabia. mhassanain@ksu.edu.sa
Research Domain of This Article
Oncology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Oct 10, 2015; 6(5): 142-146 Published online Oct 10, 2015. doi: 10.5306/wjco.v6.i5.142
Portal vein embolization effect on colorectal cancer liver metastasis progression: Lessons learned
Eman Al-Sharif, Eve Simoneau, Mazen Hassanain
Eman Al-Sharif, Mazen Hassanain, Department of Surgery, College of Medicine, King Saud University, Riyadh 11466, Saudi Arabia
Eve Simoneau, Department of Surgery, McGill University Health Center, Montreal H4A 3J1, Canada
Mazen Hassanain, Department of Oncology, McGill University Health Center, Montreal H4A 3J1, Canada
Author contributions: Al-Sharif E wrote and revised the manuscript; Simoneau E contributed to critical revision of the manuscript; Hassanain M contributed to writing the outline, critical revision and approval of the final manuscript; all authors of this paper made a substantial contribution.
Conflict-of-interest statement: The authors have no relevant financial or nonfinancial conflict of interest to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Mazen Hassanain, Associate Professor of Surgery and Consultant Hepatobiliary and Transplant Surgery, Department of Surgery, College of Medicine, Scientific Director Liver Disease Research Centre, King Saud University, PO Box 25179, Riyadh 11466, Saudi Arabia. mhassanain@ksu.edu.sa
Telephone: +966-50-5141090
Received: April 3, 2015 Peer-review started: April 5, 2015 First decision: May 13, 2015 Revised: July 7, 2015 Accepted: July 24, 2015 Article in press: July 27, 2015 Published online: October 10, 2015
Core Tip
Core tip: This article discusses the effect of portal vein embolization (PVE) on colorectal liver metastasis (CRLM) growth and the suggested methods of prevention. In addition to presenting the various experimental and clinical studies emphasizing the suggested tumoral enhancing effect of PVE, this article highlights the concept of reversal of chemotherapy response, a potential effect occurring after PVE. This observation may impact significantly subsequent patients’ management as it may affect the resectability state of patients. Moreover, potential methods to prevent tumor growth are discussed in this article, indicating the need for further research in this field and highlighting the complex interaction between CRLM and liver regeneration milieu.
