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World J Clin Oncol. Dec 10, 2014; 5(5): 874-882
Published online Dec 10, 2014. doi: 10.5306/wjco.v5.i5.874
Published online Dec 10, 2014. doi: 10.5306/wjco.v5.i5.874
Polymorphisms in base excision repair genes: Breast cancer risk and individual radiosensitivity
Clarice Patrono, Antonella Testa, Technical Unit of Radiation Biology and Human Health, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), 00123 Rome, Italy
Silvia Sterpone, Renata Cozzi, Department of Science, University “Roma TRE”, 00146 Rome, Italy
Author contributions: Patrono C and Cozzi R organised and structured the review; Patrono C wrote the paper; Sterpone S, Testa A and Cozzi R critically revised the manuscript; all authors approved the final version.
Correspondence to: Renata Cozzi, Professor, Department of Science, University “Roma TRE”, Viale G. Marconi 446, 00146 Rome, Italy. renata.cozzi@uniroma3.it
Telephone: +39-6-57336330
Received: December 29, 2013
Revised: April 3, 2014
Accepted: April 17, 2014
Published online: December 10, 2014
Processing time: 347 Days and 11.9 Hours
Revised: April 3, 2014
Accepted: April 17, 2014
Published online: December 10, 2014
Processing time: 347 Days and 11.9 Hours
Core Tip
Core tip: Single nucleotide polymorphisms (SNPs) in DNA repair genes may modulate DNA repair efficiency, influencing the development of various cancers, including breast cancer (BC). SNPs in DNA repair genes have also been studied as predictors for the risk of radiotherapy-induced side effects. We reviewed the literature on the association between SNPs in base excision repair (BER) genes and BC risk. We focused on X-ray repair cross complementing group 1, 8-oxoguanine DNA glycosylase 1, apurinic/apyrimidinic endonuclease 1 and poly (ADP-ribose) polymerase-1, which encode four important BER proteins. We also report published studies on SNPs in BER genes and individual radiosensitivity in BC patients.