Almatroodi SA, McDonald CF, Collins AL, Darby IA, Pouniotis DS. Blood classical monocytes phenotype is not altered in primary non-small cell lung cancer. World J Clin Oncol 2014; 5(5): 1078-1087 [PMID: 25493244 DOI: 10.5306/wjco.v5.i5.1078]
Corresponding Author of This Article
Saleh A Almatroodi, PhD candidate, School of Medical Sciences, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia. saleh.almatroodi@rmit.edu.au
Research Domain of This Article
Oncology
Article-Type of This Article
Research Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Dec 10, 2014; 5(5): 1078-1087 Published online Dec 10, 2014. doi: 10.5306/wjco.v5.i5.1078
Blood classical monocytes phenotype is not altered in primary non-small cell lung cancer
Saleh A Almatroodi, Christine F McDonald, Allison L Collins, Ian A Darby, Dodie S Pouniotis
Saleh A Almatroodi, Applied Medical Sciences College, Qassim University, Buraidah, Saudi Arabia
Saleh A Almatroodi, Ian A Darby, Dodie S Pouniotis, School of Medical Sciences, RMIT University, Bundoora, VIC 3083, Australia
Christine F McDonald, Allison L Collins, Institute for Breathing and Sleep, Austin Health, Heidelberg, VIC 3084, Australia
Author contributions: Almatroodi SA performed the majority of experiments, data analysis and wrote the manuscript; McDonald CF provided the collection of all the human material in addition to editing the manuscript; Collins AL involved in the collection of all the human material; Darby IA contributed in editing the manuscript; Pouniotis DS designed the study and provided reagents and analytical tools and were also involved in editing the manuscript.
Supported by The Institute for Breathing and Sleep, Austin Health, Heidelberg, VIC 3084, Australia and School of Medical Sciences, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia
Correspondence to: Saleh A Almatroodi, PhD candidate, School of Medical Sciences, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia. saleh.almatroodi@rmit.edu.au
Telephone: +61-3-99257296 Fax: +61-3-99257063
Received: August 12, 2014 Revised: October 10, 2014 Accepted: October 28, 2014 Published online: December 10, 2014 Processing time: 120 Days and 19.8 Hours
Core Tip
Core tip: Monocytes perform a critical role in immune system and have similar phenotype as seen in M1 (classically activated) and M2 (alternatively activated) tumour-associated macrophage. Nevertheless, monocyte phenotypes in human lung cancer patients are not fully understood and further investigation are really needed. Our study examines the M1 and M2 monocyte phenotypes in patients with non-small lung carcinoma [non-small cell lung cancer (NSCLC)] compared to non-cancer controls. This study indicated that freshly isolated peripheral blood monocytes from patients with NSCLC do not show an altered phenotype and/or cytokines secretion. These outcomes might enhance the knowledge regarding the connections between monocyte-macrophage phenotype and tumour progression.
