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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Dec 10, 2014; 5(5): 1002-1019
Published online Dec 10, 2014. doi: 10.5306/wjco.v5.i5.1002
Published online Dec 10, 2014. doi: 10.5306/wjco.v5.i5.1002
Immune therapy for human papillomaviruses-related cancers
Ricardo Rosales, Virolab, S de RL de CV, Cuernavaca, Morelos 17007, Mexico
Carlos Rosales, Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, DF 04510, Mexico
Author contributions: Rosales R and Rosales C wrote and reviewed the paper, and contributed equally to this work.
Supported by Virolab, S de RL de CV, and in part by Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México No. IN207514; and Consejo Nacional de Ciencia y Tecnología, Mexico, No. 168098
Correspondence to: Carlos Rosales, PhD, Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Apdo, Postal 70228, Cd. Universitaria, México City, DF 04510, Mexico. carosal@unam.mx
Telephone: +52-55-56228945 Fax: +52-55-55503982
Received: December 24, 2013
Revised: April 8, 2014
Accepted: May 28, 2014
Published online: December 10, 2014
Processing time: 352 Days and 11.6 Hours
Revised: April 8, 2014
Accepted: May 28, 2014
Published online: December 10, 2014
Processing time: 352 Days and 11.6 Hours
Core Tip
Core tip: Infection with human papillomavirus (HPV) is very common and it is associated with benign and malignant proliferation of skin and mucosae. Low-risk HPV produce warts; while high-risk HPV induce tumors. Because there are not antiviral drugs for HPV infection, current therapies involve surgical removal of the lesion. Unfortunately, after surgery many recurrences still appear and about 50% of the HPV-cancer patients die. In the past decade, new therapeutic strategies geared to generate an efficient virus-specific cytotoxic response have been developed. This review describes the current status of the several therapeutic strategies used to treat HPV-induced lesions.