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World J Clin Oncol. Aug 10, 2014; 5(3): 323-334
Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.323
Regulation of the mRNA half-life in breast cancer
Paola Griseri, Gilles Pagès
Paola Griseri, United Orthopedic Corporation, Genetica Medica, Institute Giannina Gaslini, 16148 Genoa, Italy
Gilles Pagès, University of Nice Sophia Antipolis, Institute for Research on Cancer and Aging of Nice (IRCAN) UMR CNRS/7284 U INSERM 1081, 06189 Nice, France
Author contributions: Griseri P performed literature search and wrote the paper; Pagès G designed and revised the paper
Supported by A fellowship from “Fondazione Umberto Veronesi” to Griseri P; the French National Institute of Cancer (INCA), the French Association for Cancer Research (ARC), the Fondation de France, the Conseil Général des Alpes Maritimes, Roche France and The “Association pour la Recherche sur les Tumeurs du Rein (ARTuR)”
Correspondence to: Dr. Gilles Pagès, University of Nice-Sophia Antipolis, Institute for Research on Cancer and Aging of Nice (IRCAN) UMR CNRS/7284 U INSERM 1081, 33, av. Valombrose, 06189 Nice, France. gpages@unice.fr
Telephone: +33-4-92031231 Fax: +33-4-92031235
Received: December 17, 2013
Revised: March 31, 2014
Accepted: May 13, 2014
Published online: August 10, 2014
Core Tip

Core tip: This review article is dedicated to the understanding of the mechanisms involved in the regulation of mRNA half-life. mRNA relative stability is an important way to rapidly increase or decrease the level of a given gene. This process is a much more rapid mechanism compare to transcriptional regulation. Since many genes implicated in cancerous processes are regulated at the level of their half-life, the proteins and/or small non coding RNA implicated in this regulation may serve as relevant prognosis markers or predictive markers of the efficacy of chemotherapeutic agents.