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©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Clin Oncol. May 10, 2014; 5(2): 134-141
Published online May 10, 2014. doi: 10.5306/wjco.v5.i2.134
Published online May 10, 2014. doi: 10.5306/wjco.v5.i2.134
Long non-coding RNAs in stem cells and cancer
Gabriel Eades, Yong-Shu Zhang, Qing-Lin Li, Ji-Xiang Xia, Yuan Yao, Qun Zhou, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, United States
Author contributions: Eades G generated the figure and wrote the manuscript; Zhang YS, Li QL and Xia JX contributed to the writing of the manuscript; Yao Y reviewed the manuscript; Zhou Q designed the aim of the editorial and wrote the manuscript.
Supported by ACS (Zhou Q); and NIH/NCI R01 (Zhou Q)
Correspondence to: Qun Zhou, MD, PhD, Assistant Professor, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 685 W Baltimore St 480, Baltimore, MD 21201, United States. qzhou@som.umaryland.edu
Telephone: +1-410-706-1615 Fax: +1-410-706-8297
Received: November 1, 2013
Revised: January 22, 2014
Accepted: March 3, 2014
Published online: May 10, 2014
Processing time: 192 Days and 15.8 Hours
Revised: January 22, 2014
Accepted: March 3, 2014
Published online: May 10, 2014
Processing time: 192 Days and 15.8 Hours
Core Tip
Core tip: We discuss long non-coding RNA (lncRNA) in stem cells, where they are shown to be critical regulators of pluripotency and self-renewal. Next, we examine lncRNAs role in regulating the epigenome. Finally we summarize the suspected involvement of lncRNAs in tumorigenesis.