Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Aug 24, 2025; 16(8): 108371
Published online Aug 24, 2025. doi: 10.5306/wjco.v16.i8.108371
Exploration of preventive treatment for high risk patients with metachronous multiple esophageal squamous cell carcinoma: A case report
Dan Chen, Ding-Fu Zhong, Dong Liu
Dan Chen, Ding-Fu Zhong, Department of Gastroenterology, Affiliated Jinhua Hospital of Wenzhou Medical University, Jinhua People’s Hospital, Jinhua 321000, Zhejiang Province, China
Dong Liu, Department of Hepatobiliary and Pancreatic Gastroenterology, Affiliated Jinhua Hospital of Wenzhou Medical University, Jinhua People’s Hospital, Jinhua 321000, Zhejiang Province, China
Author contributions: Chen D, Zhong DF, and Liu D collected and analyzed the data; Chen D and Liu D drafted the manuscript; Liu D critically revised paper; and all authors have read and approved the final version to be published.
Supported by Jinhua City Science and Technology Plan Projects, No. 2022-4-145.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest related to this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dong Liu, Associate Chief Physician, Department of Hepatobiliary and Pancreatic Gastroenterology, Affiliated Jinhua Hospital of Wenzhou Medical University, Jinhua People’s Hospital, No. 267 Danxi East Road, Jindong District, Jinhua 321000, Zhejiang Province, China. li375dong@163.com
Received: April 23, 2025
Revised: June 14, 2025
Accepted: July 17, 2025
Published online: August 24, 2025
Processing time: 119 Days and 20.4 Hours
Core Tip

Core Tip: The grade of Lugol-voiding lesions is associated with risk of metachronous squamous cell carcinomas (SCCs). Effective methods to prevent metachronous multiple SCCs are needed in survivors of esophageal squamous cell carcinomas. We present the first case of multiple dysplastic lesions of esophagus cured by radiotherapy. This case indicated that radiotherapy after endoscopic submucosal dissection might be a safe and effective optional therapeutic strategy to prevent metachronous multiple esophageal SCCs.