Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Aug 24, 2025; 16(8): 107208
Published online Aug 24, 2025. doi: 10.5306/wjco.v16.i8.107208
GPR81 nuclear transportation is critical for cancer growth and progression in lung and other solid cancers
LiBang Yang, Thomas Kono, Adam Gilbertsen, Yingming Li, Bo Sun, Blake A Jacobson, Sabine Karam, Scott M Dehm, Craig A Henke, Robert A Kratzke
LiBang Yang, Adam Gilbertsen, Craig A Henke, Department of Medicine, University of Minnesota, Minnesota 55455, MN, United States
Thomas Kono, Minnesota Supercomputing Institute, University of Minnesota, Minnesota 55455, MN, United States
Yingming Li, Scott M Dehm, Masonic Cancer Center, Department of Medicine, University of Minnesota, Minnesota 55455, MN, United States
Bo Sun, Division of Gastro, Hepatology, Nutrition, Department of Medicine, University of Minnesota, Minnesota 55455, MN, United States
Blake A Jacobson, Robert A Kratzke, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minnesota 55455, MN, United States
Sabine Karam, Division of Nephrology, Department of Medicine, University of Minnesota, Minnesota 55455, MN, United States
Author contributions: Yang L and Kratzke RA conceived, designed, and directed the studies; Henke CA, Karem S, Dehm SM provided cell lines and analyzed the data; Yang L, Gilbertsen A, Li Y, Sun B and Jacobson B established primary human cell lines, performed Q-PCR, western blot analysis, performed gain and loss of function experiments, mouse studies, and immunohistochemistry; Kono T processed and analyzed the ChIP seq data.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the University of Minnesota.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the University of Minnesota.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data that support the findings of this study are available on request from the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: LiBang Yang, MD, PhD, Senior Researcher, Department of Medicine, University of Minnesota, 420 Delaware Street, Minneapolis, MN 55455, United States. yangx822@umn.edu
Received: March 18, 2025
Revised: May 19, 2025
Accepted: July 8, 2025
Published online: August 24, 2025
Processing time: 155 Days and 16.9 Hours
Core Tip

Core Tip: Lactate promotes GPR81 expression and nuclear transportation. where GPR81 interacts with nuclear proteins and regulates cancer cell function. Then targeting GPR81 and its nuclear transportation provides an opportunity to develop novel treatments targeting cancers.