Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Apr 24, 2025; 16(4): 105077
Published online Apr 24, 2025. doi: 10.5306/wjco.v16.i4.105077
Oxaliplatin-induced diffuse alveolar hemorrhage: A case report
Toshiaki Tsurui, Emiko Mura, Atsushi Horiike, Takuya Tsunoda
Toshiaki Tsurui, Emiko Mura, Atsushi Horiike, Takuya Tsunoda, Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo 1428555, Tōkyō, Japan
Author contributions: Tsurui T conceptualized the study and drafted the manuscript; Mura E coordinated the study; Mura E, Horiike A, and Tsunoda T revised the manuscript; and all authors have read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient for publication of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Toshiaki Tsurui, MD, Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 1428555, Tōkyō, Japan. t.tsurui@med.showa-u.ac.jp
Received: January 11, 2025
Revised: February 4, 2025
Accepted: February 27, 2025
Published online: April 24, 2025
Processing time: 75 Days and 1.1 Hours
Core Tip

Core Tip: This report describes a case of a serious complication of oxaliplatin-induced diffuse alveolar hemorrhage. The diagnosis of diffuse alveolar hemorrhage (DAH) is challenging because the clinical manifestations and radiographic findings of DAH, such as diffuse bilateral opacities, are non-specific, necessitating bronchoscopy with bronchoalveolar lavage fluid analysis to establish the diagnosis of DAH. As early diagnosis by bronchoscopy and prompt initiation of corticosteroid treatment were essential for saving the patient, clinicians should be aware that diffuse alveolar hemorrhage is a potential cause of respiratory failure in patients receiving oxaliplatin.