Candida albicans and colorectal cancer: A paradoxical role revealed through metabolite profiling and prognostic modeling

doi:10.5306/wjco.v16.i4.104182

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World Journal of Clinical Oncology

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2218-4333

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Basic Study

World J Clin Oncol. Apr 24, 2025; 16(4): 104182
Published online Apr 24, 2025. doi: 10.5306/wjco.v16.i4.104182

Candida albicans and colorectal cancer: A paradoxical role revealed through metabolite profiling and prognostic modeling

Hao-Ling Zhang, Rui Zhao, Di Wang, Siti Nurfatimah Mohd Sapudin, Badrul Hisham Yahaya, Mohammad Syamsul Reza Harun, Zhong-Wen Zhang, Zhi-Jing Song, Yan-Ting Liu, Sandai Doblin, Ping Lu

Hao-Ling Zhang, Yan-Ting Liu, Ping Lu, Department of Oncology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453000, Henan Province, China

Hao-Ling Zhang, Di Wang, Department of Biomedical Science, Universiti Sains Malaysia, Pinang 13200, Malaysia

Rui Zhao, Zhi-Jing Song, Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China

Siti Nurfatimah Mohd Sapudin, Badrul Hisham Yahaya, Mohammad Syamsul Reza Harun, Sandai Doblin, Department of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang 13200, Malaysia

Zhong-Wen Zhang, School of Public Health, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China

Co-corresponding authors: Sandai Doblin and Lu Ping.

Author contributions: Zhang HL completed the first draft of the paper and finished the data processing; Zhao R, Wang D, Lok B, Mohd Sapudin SN, Yahaya BH, and Harun MSR completed the data check of the paper and provided suggestions for revision; Sandai D, Zhang ZW, Song ZJ, Liu YT, and Lu P revised the article.

Supported by Gansu Province Joint Fund General Program, No. 24JRRA878; Gansu Provincial Science and Technology Program Project, No. 24JRRA1020; Gansu Province Key Talent Program, No. 2025RCXM006; Teaching Research and Reform Program for Postgraduate Education at Gansu University of Traditional Chinese Medicine (GUSTCM), No. YBXM-202406; and Special Fund for Mentors of “Qihuang Talents” in the First-Level Discipline of Chinese Medicine, No. ZYXKBD-202415.

Institutional review board statement: This study was approved by Gansu University of Chinese Medicine and supported by Professor Zhijing Song from Gansu University of Chinese Medicine and Professor Ping Lu from the First Affiliated Hospital of Xinxiang Medical College.

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

Data sharing statement: The data supporting the findings of this study are available from the corresponding author (or first author) upon reasonable request. Access to the data will be provided under appropriate conditions, ensuring that confidentiality and ethical standards are maintained.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ping Lu, Professor, Department of Oncology, The First Affiliated Hospital of Xinxiang Medical University Weihui, Xinxiang 453000, Henan Province, China. lupingdoctor@163.com

Received: December 13, 2024
Revised: January 11, 2025
Accepted: January 23, 2025
Published online: April 24, 2025
Processing time: 104 Days and 2.2 Hours

Core Tip

Core Tip: This study explored the paradoxical role of Candida albicans (C. albicans) in colorectal cancer (CRC), focusing on its tumor-modulating effects through metabolic interactions. A novel prognostic model incorporating five mRNA markers, EHD4, LIME1, GADD45B, TIMP1, and FDFT1, was developed, providing a framework for CRC risk assessment. The C. albicans metabolite mixture demonstrated a significant inhibitory effect on CRC initiation by reducing cell viability, altering gene expression, impairing migratory and invasive abilities, and promoting apoptosis without affecting reactive oxygen species accumulation. The study highlighted the potential of C. albicans metabolites as a therapeutic avenue in CRC management.