Emerging salivary biomarkers for early detection of oral squamous cell carcinoma

doi:10.5306/wjco.v16.i4.103803

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Apr 24, 2025 (publication date) through Mar 29, 2025

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World Journal of Clinical Oncology

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2218-4333

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World J Clin Oncol. Apr 24, 2025; 16(4): 103803
Published online Apr 24, 2025. doi: 10.5306/wjco.v16.i4.103803

Emerging salivary biomarkers for early detection of oral squamous cell carcinoma

Cheng-Chen Hu, Sheng-Guo Wang, Zhi Gao, Mao-Feng Qing, Shan Pan, Ying-Ying Liu, Fang Li

Cheng-Chen Hu, Sheng-Guo Wang, Zhi Gao, Mao-Feng Qing, Shan Pan, Ying-Ying Liu, Department of Stomatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China

Fang Li, Department of General Surgery, Chongqing General Hospital, Chongqing 401147, China

Author contributions: Hu CC and Li F contributed to the conceptualization, writing, and editing of this manuscript; Hu CC, Qing MF, Pan S, and Liu YY contributed to the article screening and writing; Wang SG and Gao Z contributed to the literature search. All the authors have read and agreed to the published version of the manuscript.

Conflict-of-interest statement: The authors declare no conflicts of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Fang Li, MD, PhD, Professor, Department of General Surgery, Chongqing General Hospital, No. 118 Xingguang Avenue, Liangjiang New District, Chongqing 401147, China. leef123456@163.com

Received: December 2, 2024
Revised: January 23, 2025
Accepted: March 6, 2025
Published online: April 24, 2025
Processing time: 115 Days and 9.4 Hours

Core Tip

Core Tip: Salivary biomarkers, such as interleukin-6, interleukin-8, microRNAs, and DNA methylation patterns, have emerged as non-invasive tools for the early detection of oral squamous cell carcinoma. This review highlights recent advancements in salivary biomarker research, focusing on their diagnostic potential and the integration of cutting-edge technologies, including mass spectrometry and nanobiosensors. By addressing current challenges like assay standardization and saliva variability, this study underscores the transformative potential of salivary diagnostics in improving early oral squamous cell carcinoma detection and patient outcomes.