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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Apr 24, 2025; 16(4): 102565
Published online Apr 24, 2025. doi: 10.5306/wjco.v16.i4.102565
Published online Apr 24, 2025. doi: 10.5306/wjco.v16.i4.102565
Construction and validation of a novel prognostic nomogram for patients with poorly differentiated gastric neuroendocrine neoplasms
Ben-Long Zhang, Department of Breast and Thyroid Surgery, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou 570208, Hainan Province, China
Fei Peng, Department of Gastrointestinal Surgery, Zhongxian People’s Hospital of Chongqing, Chongqing 400000, China
Li Li, Yun-He Gao, Zi-Jian Wang, Lin Chen, Ke-Cheng Zhang, Department of General Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
Yi-Xun Lu, Department of Anesthesiology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
Co-first authors: Ben-Long Zhang and Fei Peng.
Author contributions: Zhang BL, Peng F, and Li L reviewed the literature, collected data, analyzed data, and drafted the manuscript; Zhang BL and Peng F they contributed equally to this article, they are the co-first authors of this manuscript; Zhang KC and Chen L conceived and designed the study and finalized manuscript; Gao YH, Wang ZJ, and Lu YX revised the manuscript; and all authors made significant contributions to this paper and approved the submitted version.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the Chinese PLA General Hospital, approval No. S2022-137-01.
Informed consent statement: The informed consent was waived by the Institutional Review Board.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data involved in this study can be obtained from the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ke-Cheng Zhang, PhD, Professor, Department of General Surgery, The First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. zhangkecheng@301hospital.com.cn
Received: October 22, 2024
Revised: January 3, 2025
Accepted: January 17, 2025
Published online: April 24, 2025
Processing time: 155 Days and 10 Hours
Revised: January 3, 2025
Accepted: January 17, 2025
Published online: April 24, 2025
Processing time: 155 Days and 10 Hours
Core Tip
Core Tip: This single-center retrospective study investigates the clinicopathological characteristics of patients with poorly differentiated gastric neuroendocrine neoplasms and develops a prognostic prediction model. A total of 336 patients were included, making it the largest single-center cohort globally. Key findings indicate that platelet-to-lymphocyte ratio, age, Ki-67 index, invasion depth, lymph node metastasis, and distant metastasis are independent risk factors for survival. The nomogram prediction model demonstrated superior predictive accuracy and clinical usefulness compared to the tumor-node-metastasis staging system.