Meta-Analysis
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Apr 24, 2025; 16(4): 102397
Published online Apr 24, 2025. doi: 10.5306/wjco.v16.i4.102397
Relationship between Helicobacter pylori infection and programmed death-ligand 1 in gastric cancer: A meta-analysis
Hong-Chang Yang, Cheng-Feng Fu, Li-Jun Qiao, Gen-He Long, Li-Fen Yang, Biao Yao
Hong-Chang Yang, Department of Gastroenterology, Longgang Central Hospital of Shenzhen, Shenzhen 518100, Guangdong Province, China
Cheng-Feng Fu, Li-Fen Yang, Biao Yao, Department of Oncology, Tongren People’s Hospital, Tongren 554300, Guizhou Province, China
Li-Jun Qiao, Department of Basic Medical Sciences, Guizhou Health Vocational College, Tongren 554300, Guizhou Province, China
Gen-He Long, Department of School of Medicine, Guizhou Vocational and Technical College, Tongren 554300, Guizhou Province, China
Author contributions: Yang HC designed the report and performed the statistical analyses; Qiao LJ and Long GH collected the clinical data; Yang LF responsible for data sorting; Yao B provided key intellectual discussions; Fu CF performed the final revision and translation of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Cheng-Feng Fu, Department of Oncology, Tongren People’s Hospital, No. 120 Taoyuan Avenue, Tongren 554300, Guizhou Province, China. fcf930128@163.com
Received: October 16, 2024
Revised: December 4, 2024
Accepted: February 6, 2025
Published online: April 24, 2025
Processing time: 161 Days and 3.2 Hours
Core Tip

Core Tip: This meta-analysis investigated the relationship between Helicobacter pylori infection and programmed death-ligand 1 expression in gastric cancer (GC). Fourteen studies with 3069 GC patients were included. Results showed a significant association. Sensitivity and subgroup analyses confirmed the robustness. Publication bias was minimal. Helicobacter pylori infection may influence the response to programmed cell death protein 1/programmed death-ligand 1 blockade therapy in GC patients, but further research is needed to clarify the underlying mechanisms and clinical implications.