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World J Clin Oncol. Apr 24, 2025; 16(4): 101548
Published online Apr 24, 2025. doi: 10.5306/wjco.v16.i4.101548
Cytochrome P450 3A gene family in gastric cancer: Unveiling diagnostic biomarkers and therapeutic targets for personalized treatment
Jun-Kun Zhu, Jing Wang
Jun-Kun Zhu, Department of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China
Jing Wang, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, Guangdong Province, China
Author contributions: Zhu JK was responsible for the conceptualization and formulation of the research objectives, and completed the majority of the original draft writing and figure creation, thereby making the primary contribution to the core content of the paper; Wang J supplemented the details of the initial draft (writing, review, and editing) and optimized the overall structure and format of the paper to ensure its logical coherence and readability; Zhu JK and Wang J jointly conducted a literature search and organization of resources, providing the necessary theoretical support for the writing of the paper; and all authors reviewed the final manuscript and agreed to its publication.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun-Kun Zhu, Department of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, China. 1155215781@link.cuhk.edu.hk
Received: September 18, 2024
Revised: January 12, 2025
Accepted: February 21, 2025
Published online: April 24, 2025
Processing time: 188 Days and 19.8 Hours
Core Tip

Core Tip: Although the role of cytochrome P450 3A (CYP3A) enzymes in gastric cancer remains underexplored, this review synthesizes existing evidence to reveal their involvement in tumor growth, migration, and resistance to chemotherapy. By integrating insights into CYP3A polymorphisms and their influence on drug metabolism, the study provides a potential framework for developing personalized treatment strategies aimed at improving patient outcomes.