Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Mar 24, 2025; 16(3): 100723
Published online Mar 24, 2025. doi: 10.5306/wjco.v16.i3.100723
Role of octamer transcription factor 4 in proliferation, migration, drug sensitivity, and stemness maintenance of pancreatic cancer cells
Xue-Ying Shi, Xi-Lan Wang, Jin Zhao, Shi-Hai Yang, Cheng-Hai Zhang
Xue-Ying Shi, Jin Zhao, Shi-Hai Yang, Cheng-Hai Zhang, Department of General Surgery, The Third Affiliated Hospital, Inner Mongolia Medical University, Baotou 014010, Inner Mongolia Autonomous Region, China
Xi-Lan Wang, Department of Gastroenterology, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China
Co-first authors: Xue-Ying Shi and Xi-Lan Wang.
Co-corresponding authors: Jin Zhao and Shi-Hai Yang.
Author contributions: Shi XY and Wang XL were responsible for the project design; Shi XY, Wang XL, Zhang CH, and Yang SH performed the experiments and analyzed the data; Wang XL drafted the manuscript; Zhao J revised the manuscript. Shi XY and Wang XL contributed equally to this work as co-first authors. First, the two co-corresponding authors play an equal role in revising the manuscript; Secondly, as the corresponding author Zhao J is the director of the department, the daily operation is relatively large and busy, in many cases, we have to entrust Yang SH (another corresponding author) to pay more attention to the email exchanges with your journal, and inform Zhao J to jointly revise the manuscript according to the revision opinions of your journal.
Supported by Inner Mongolia Natural Science Foundation and the 3rd Affiliated of Inner Medical University, No. 2021MS08067.
Institutional review board statement: Paraffin samples from human pancreatic cancer were approved by the committee on the Ethics of Shanghai Xinchao Biological Technology Co., LTD.
Conflict-of-interest statement: The authors declare that there is no conflict of interest regarding the publication of the article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin Zhao, MMed, Chief Doctor, Department of General Surgery, The Third Affiliated Hospital, Inner Mongolia Medical University, No. 20 Shaoxian Street, Baotou 014010, Inner Mongolia Autonomous Region, China. zhaojin20072008@163.com
Received: August 24, 2024
Revised: November 18, 2024
Accepted: December 13, 2024
Published online: March 24, 2025
Processing time: 149 Days and 21.2 Hours
Core Tip

Core Tip: This study introduces a novel perspective on Octamer transcription factor 4 (OCT4)'s role in pancreatic cancer (PC) stem cells (PCSCs) and demonstrated that OCT4 overexpression enhances activity and drug resistance of PCSCs, with notable implications for PC treatment.