Molecular mechanism of pancreatic ductal adenocarcinoma: The heterogeneity of cancer-associated fibroblasts and key signaling pathways

doi:10.5306/wjco.v16.i2.97007

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World Journal of Clinical Oncology

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World J Clin Oncol. Feb 24, 2025; 16(2): 97007
Published online Feb 24, 2025. doi: 10.5306/wjco.v16.i2.97007

Molecular mechanism of pancreatic ductal adenocarcinoma: The heterogeneity of cancer-associated fibroblasts and key signaling pathways

Zhong-Yuan Hu, Ding Ding, Yu Song, Ya-Feng Deng, Cheng-Ming Zhang, Tao Yu

Zhong-Yuan Hu, Ding Ding, First School of Clinical Medicine, Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China

Yu Song, College of Acupuncture and Massage, Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China

Ya-Feng Deng, Graduate School, Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China

Cheng-Ming Zhang, Tao Yu, Digestive Department I, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi’an 710000, Shaanxi Province, China

Co-first authors: Zhong-Yuan Hu and Ding Ding.

Author contributions: Hu ZY and Ding D designed and finalized the overall structure of the manuscript; Song Y, Deng YF and Zhang CM played a significant role in the discussion and design of the manuscript; Yu T was responsible for writing, editing, and conducting the literature review. Hu ZY and Ding D contributed equally to this work as co-first authors.

Supported by National Key Research and Development Program Project, No. 2017YFC1700601; Shaanxi Provincial Key Research and Development Program Project, No. 2018SF-350; and Leading Talents in Scientific and Technological Innovation of the Shaanxi Province Special Support Plan, No. 00518.

Conflict-of-interest statement: None of the authors have any relevant conflicts of interest to disclose concerning this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Tao Yu, MS, Chief Doctor, Digestive Department I, Shaanxi Provincial Hospital of Traditional Chinese Medicine, No. 4 Ming Palace Road, Lianhu District, Xi’an 710000, Shaanxi Province, China. yt0745@163.com

Received: May 20, 2024
Revised: October 4, 2024
Accepted: November 4, 2024
Published online: February 24, 2025
Processing time: 204 Days and 19.1 Hours

Core Tip

Core Tip: This research explored the mechanisms of action of fibroblasts in pancreatic tumors and revealed their effects on the tumor microenvironment. This study revealed that fibroblasts enhance tumor growth and metastasis through specific signaling pathways, suggesting that targeting fibroblasts may emerge as a new strategy for treating pancreatic cancer.