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Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Sep 24, 2024; 15(9): 1136-1156
Published online Sep 24, 2024. doi: 10.5306/wjco.v15.i9.1136
Colorectal cancer: Recent advances in management and treatment
Hiba Fadlallah, Jad El Masri, Hiam Fakhereddine, Joe Youssef, Chrystelle Chemaly, Samer Doughan, Wassim Abou-Kheir
Hiba Fadlallah, Jad El Masri, Hiam Fakhereddine, Joe Youssef, Chrystelle Chemaly, Wassim Abou-Kheir, Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut 1107-2020, Lebanon
Samer Doughan, Department of Surgery, American University of Beirut Medical Center, Beirut 1107-2020, Lebanon
Co-first authors: Hiba Fadlallah and Jad El Masri.
Co-corresponding authors: Samer Doughan and Wassim Abou-Kheir.
Author contributions: Fadlallah H, El Masri J, Fakhereddine H, Youssef J, and Chemaly C wrote the manuscript; Doughan S and Abou-Kheir W revised the manuscript; All authors have read and approved the final manuscript. Fadlallah H and El Masri J contributed equally to this work, in writing the manuscript. Abou-Kheir W and Doughan S contributed equally to this work in revising the manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wassim Abou-Kheir, PhD, Associate Professor, Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Bliss Street, Hamra, Beirut 1107-2020, Lebanon. wa12@aub.edu.lb
Received: December 27, 2023
Revised: June 11, 2024
Accepted: July 29, 2024
Published online: September 24, 2024
Processing time: 245 Days and 11.5 Hours
Core Tip

Core Tip: As one of the most prevalent cancers worldwide, research efforts have focused on finding new treatment modalities for colorectal cancer (CRC), with higher efficiency and better overall survival rates. Current management options include surgery, chemotherapy, immunotherapy, radiation therapy, and targeted therapy. Despite all efforts, CRC is still highly incurable, necessitating additional research in this field. This review summarizes recent advances in therapeutic approaches targeting CRC.