Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Aug 24, 2024; 15(8): 968-974
Published online Aug 24, 2024. doi: 10.5306/wjco.v15.i8.968
Pyroptosis: A promising biomarker for predicting colorectal cancer prognosis and enhancing immunotherapy efficacy
Jia-Yi Wang, Yu-Hao Lu, Fang Li, Mo-Li Huang
Jia-Yi Wang, Yu-Hao Lu, Fang Li, Mo-Li Huang, School of Biology and Basic Medical Sciences, Medical College of Soochow University, Suzhou 215123, Jiangsu Province, China
Author contributions: Wang JY and Lu YH contributed to manuscript writing; Huang ML designed the overall concept and outline of the manuscript; Li F and Huang ML contributed to manuscript revision; all authors approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 32370598 and No. 31971117.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mo-Li Huang, PhD, Professor, School of Biology and Basic Medical Sciences, Medical College of Soochow University, No. 199 Renai Road, Suzhou 215123, Jiangsu Province, China. huangml@suda.edu.cn
Received: March 14, 2024
Revised: May 24, 2024
Accepted: July 2, 2024
Published online: August 24, 2024
Processing time: 155 Days and 4.8 Hours
Core Tip

Core Tip: Pyroptosis plays a vital role in tumor immunotherapy by triggering robust inflammatory responses and significantly inhibiting tumors. Pyroptosis results in the release of copious amounts of inflammatory cytokines and tumor-associated antigens that stimulate antigen-presenting cells, thereby initiating adaptive immune responses. Therefore, inducing pyroptosis is a promising novel immunotherapy approach for tumors.