Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jul 24, 2024; 15(7): 953-960
Published online Jul 24, 2024. doi: 10.5306/wjco.v15.i7.953
Amelanotic primary cervical malignant melanoma: A case report and review of literature
Jin-Lin Duan, Jing Yang, Yong-Long Zhang, Wen-Tao Huang
Jin-Lin Duan, Jing Yang, Wen-Tao Huang, Department of Pathology, The Affiliated Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200332, China
Yong-Long Zhang, Laboratory of Targeted Therapy and Precision Medicine, Department of Clinical Laboratory, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
Author contributions: Duan JL and Yang Y contributed to the histological examinations and collection of patient data; Duan JL and Yang Y assembled the data; Huang WT and Zhang YL performed data analysis and interpretation; Huang WT, Duan JL, and Zhang YL wrote the manuscript; All authors read and approved the final manuscript; Huang WT and Zhang YL confirm the authenticity of all the raw data; Duan JL and Yang J contributed equally to this work.
Supported by the National Natural Science Foundation of China, No. 82073258; the Excellent Youth Program of Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. ynyq202105; the Research Fund of Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No. TRYJ201702; Start-up Funding for Talent Introduction, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No. TR2020rc04; and Special Project of Medical and Health Research in Changning District, Shanghai, No. CNKW2017Y09.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors have no conflicts of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Tao Huang, MD, Director, Department of Pathology, The Affiliated Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, No. 1111 Xianxia Road, Changning District, Shanghai 200332, China. wt.huang@hotmail.com
Received: March 20, 2024
Revised: May 8, 2024
Accepted: June 7, 2024
Published online: July 24, 2024
Processing time: 117 Days and 14.7 Hours
Core Tip

Core Tip: We report a case of unsuspected amelanotic primary malignant melanoma of the cervix (PMMC) with a history of breast cancer. The patient underwent radical hysterectomy, bilateral salpingo-oophorectomy and pelvic lymphadenectomy, and then received radiotherapy combined with immunotherapy. She has remained free of disease for more than 1 year. The successful management of this patient underscores the critical role of routine immunohistochemical staining during cervical cancer diagnosis to exclude unsuspected PMMC, and adjuvant immunotherapy may be an option for PMMC.