Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jul 24, 2024; 15(7): 936-944
Published online Jul 24, 2024. doi: 10.5306/wjco.v15.i7.936
Rare primary squamous cell carcinoma of the intrahepatic bile duct: A case report and review of literature
Qing-Jun Ma, Fu-Hai Wang, Ning-Ning Yang, Hong-Long Wei, Feng Liu
Qing-Jun Ma, Fu-Hai Wang, Hong-Long Wei, Feng Liu, Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan 250014, Shandong Province, China
Ning-Ning Yang, Department of Respiratory and Critical Care Medicine, Shandong Provincial Chest Hospital Affiliated to Shandong University, Jinan 250013, Shandong Province, China
Co-first authors: Qing-Jun Ma and Ning-Ning Yang.
Author contributions: Ma QJ and Yang NN designed the report and wrote the paper, they contributed equally to this manuscript; Wang FH and Liu F performed the surgery; Wei HL collected the patient’s clinical data; Wang FH analyzed the data and revised the paper; all authors have read and approved the final version of this manuscript.
Supported by the Youth Science Foundation Grant Program of Shandong First Medical University, No. 202201-091.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4. 0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons. org/Licenses/by-nc/4.0/
Corresponding author: Fu-Hai Wang, MD, Surgeon, Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University, No. 16766 Jingshi Road, Jinan 250014, Shandong Province, China. 2139@sdhospital.com.cn
Received: February 26, 2024
Revised: June 3, 2024
Accepted: June 25, 2024
Published online: July 24, 2024
Processing time: 140 Days and 14.9 Hours
Core Tip

Core Tip: We report a case of primary intrahepatic biliary squamous cell carcinoma (SCC) that was initially considered hepatocellular carcinoma. Intrahepatic biliary SCC is a rare pathological type without typical imaging features or serum markers. Its diagnosis depends on biopsy or postoperative pathology. Surgical resection is still considered the first choice for resectable lesions, but the intraoperative pathology of atypical liver lesions is essential for radical resection. Combined chemotherapy or chemoradiotherapy is beneficial for prolonging overall survival and decreasing the risk of recurrence. This case report and related literature review provide a valuable reference for the diagnosis and treatment of this disease.