Savvidis C, Kallistrou E, Kouroglou E, Dionysopoulou S, Gavriiloglou G, Ragia D, Tsiama V, Proikaki S, Belis K, Ilias I. Circadian rhythm disruption and endocrine-related tumors. World J Clin Oncol 2024; 15(7): 818-834 [DOI: 10.5306/wjco.v15.i7.818]
Corresponding Author of This Article
Ioannis Ilias, MD, PhD, Director, Department of Endocrinology, Hippocration General Hospital, 63 Evrou Str, Athens GR-11527, Greece. iiliasmd@yahoo.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Jul 24, 2024; 15(7): 818-834 Published online Jul 24, 2024. doi: 10.5306/wjco.v15.i7.818
Circadian rhythm disruption and endocrine-related tumors
Christos Savvidis, Efthymia Kallistrou, Eleni Kouroglou, Sofia Dionysopoulou, Georgios Gavriiloglou, Dimitra Ragia, Vasiliki Tsiama, Stella Proikaki, Konstantinos Belis, Ioannis Ilias
Christos Savvidis, Efthymia Kallistrou, Eleni Kouroglou, Sofia Dionysopoulou, Georgios Gavriiloglou, Dimitra Ragia, Vasiliki Tsiama, Stella Proikaki, Konstantinos Belis, Ioannis Ilias, Department of Endocrinology, Hippocration General Hospital, Athens GR-11527, Greece
Co-first authors: Christos Savvidis and Efthymia Kallistrou.
Author contributions: Savvidis C, Kallistrou E, Kouroglou E, Dionysopoulou S, Gavriiloglou G, Ragia D, Tsiama V, Proikaki S, Belis K, and Ilias I have researched the literature and contributed to the draft of this review article; Savvidis C, Kallistrou E and Ilias I revised the final article; Savvidis C and Ilias I contributed to artwork. Savvidis C and Kallistrou E contributed equally as co-first authors.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest regarding this work.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ioannis Ilias, MD, PhD, Director, Department of Endocrinology, Hippocration General Hospital, 63 Evrou Str, Athens GR-11527, Greece. iiliasmd@yahoo.com
Received: December 30, 2023 Revised: June 20, 2024 Accepted: June 27, 2024 Published online: July 24, 2024 Processing time: 198 Days and 16.8 Hours
Core Tip
Core Tip: This review explored the pivotal role of circadian clocks in physiological processes and adverse health outcomes, including metabolic syndrome and cancer, linked to their disruption. Orchestrated by interlocked CLOCK genes, the circadian system regulates vital functions, from sleep-wake cycles to immune response. Disruptions, often from night shift work, correlate with increased risks, notably in endocrine tumors. Molecular insights highlight potential therapeutic vistas, emphasizing the need for integrating circadian considerations in personalized healthcare. Chronotherapy emerges as a promising approach for endocrine tumor treatment, urging further research into precise mechanisms and public health interventions to mitigate lifestyle-related circadian disruptions.
