Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jun 24, 2024; 15(6): 755-764
Published online Jun 24, 2024. doi: 10.5306/wjco.v15.i6.755
Tankyrase 2 promotes lung cancer cell malignancy
Ying Wang, Yong-Jun Zhang
Ying Wang, Department of Gynecological Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China
Yong-Jun Zhang, Department of Integrated Traditional Chinese and Western Medicine, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China
Author contributions: Wang Y and Zhang YJ designed the research study; Zhang YJ performed the research, analyzed the data, and wrote the manuscript; Wang Y revised the manuscript. All the authors have read and approved the final manuscript.
Supported by Traditional Chinese Medicine Foundation of Zhejiang Province, No. 2019ZA020.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset are available from the corresponding author at zhangyongjun770323@163.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong-Jun Zhang, MMed, Associate Chief Physician, Department of Integrated Traditional Chinese and Western Medicine, Zhejiang Cancer Hospital, No. 1 Banshan Eastern Road, Hangzhou 310022, Zhejiang Province, China. zhangyongjun770323@163.com
Received: February 25, 2024
Revised: May 9, 2024
Accepted: May 28, 2024
Published online: June 24, 2024
Processing time: 119 Days and 18 Hours
Core Tip

Core Tip: This study provides a comprehensive overview of the role of tankyrase 2 (TNKS2) overexpression, which facilitates β-catenin activation and nuclear accumulation of β-catenin protein in non-small cell lung cancer (NSCLC) cells, in turn contributing to disease onset and progression. The findings obtained herein elucidate that TNKS2 is a putative molecular target candidate, which would serve as a prognostic indicator and a therapeutic agent for NSCLC patients.