New targets for cancer promotion and therapy in gliomas: Scinderin

doi:10.5306/wjco.v15.i6.687

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Jun 24, 2024 (publication date) through Nov 28, 2024

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World Journal of Clinical Oncology

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Jun 24, 2024; 15(6): 687-690
Published online Jun 24, 2024. doi: 10.5306/wjco.v15.i6.687

New targets for cancer promotion and therapy in gliomas: Scinderin

Xi Wang, Lian-Xiang Luo

Xi Wang, The First Clinical College, Guangdong Medical University, Zhanjiang 524023, Guangdong Province, China

Lian-Xiang Luo, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524000, Guangdong Province, China

Author contributions: Luo LX conceived and designed the editorial, contributed to the topic selection, outline formulation, and finalization of the editorial, reviewed the paper and provided comments; Wang X wrote the editorial; and all authors read and approved the final manuscript.

Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Lian-Xiang Luo, PhD, Adjunct Associate Professor, The Marine Biomedical Research Institute, Guangdong Medical University, No. 2 Wenming East Road, Zhanjiang 524000, Guangdong Province, China. luolianxiang321@gdmu.edu.cn

Received: January 3, 2024
Revised: April 27, 2024
Accepted: May 20, 2024
Published online: June 24, 2024
Processing time: 173 Days and 7.5 Hours

Core Tip

Core Tip: The role of scinderin (SCIN) in cancer progression has been studied, but its role in glioma remains unknown. Lin et al found that the expression level of SCIN mRNA was positively correlated with the tumor grade of glioma. SCIN affected cytoskeletal remodeling and inhibited lamellipodia formation through RhoA/FAK signaling pathway, thereby facilitating the migration and invasion of glioma cells.