Observational Study
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World J Clin Oncol. Feb 24, 2024; 15(2): 290-301
Published online Feb 24, 2024. doi: 10.5306/wjco.v15.i2.290
Prevalence, risk factors, and BRAF mutation of colorectal sessile serrated lesions among Vietnamese patients
Nhu Thi Hanh Vu, Huy Minh Le, Diem Thi-Ngoc Vo, Hoang Anh Vu, Nhan Quang Le, Dung Dang Quy Ho, Duc Trong Quach
Nhu Thi Hanh Vu, Duc Trong Quach, Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh 700000, Viet Nam
Nhu Thi Hanh Vu, Huy Minh Le, Nhan Quang Le, Duc Trong Quach, GI Endoscopy Department, University Medical Center at Ho Chi Minh City, Ho Chi Minh 700000, Viet Nam
Huy Minh Le, Diem Thi-Ngoc Vo, Department of Histology-Embryology and Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh 700000, Viet Nam
Hoang Anh Vu, Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh 700000, Viet Nam
Dung Dang Quy Ho, Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh 700000, Viet Nam
Author contributions: Quach DT contributed to the study’s conception; Vu NTH, Le NQ, Le HM, Vo DTN, and Vu HA conducted data curation; Vu NTH, and Quach DT performed data analysis; Ho DDQ, Quach DT, Le NQ, and Le HM provided supervision for the study; Vu NTH, Quach DT, and Vu HA drafted the initial manuscript; Ho DDQ, Vo DTN, Quach DT, Le HM, Le NQ, and Vu HA reviewed and edited the manuscript.
Institutional review board statement: The study was approved by the Board of Ethics in Biomedical Research of the University of Medicine and Pharmacy at Ho Chi Minh City (ID number: 615/HDDD-DHYD, signed on November 19, 2021).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Duc Trong Quach, MD, PhD, Associate Professor, Senior Lecturer, Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang Street, District 5, Ho Chi Minh 700000, Viet Nam. duc.qt@umc.edu.vn
Received: December 13, 2023
Peer-review started: December 13, 2023
First decision: December 22, 2023
Revised: December 25, 2023
Accepted: January 12, 2024
Article in press: January 12, 2024
Published online: February 24, 2024
Processing time: 68 Days and 21.3 Hours
Core Tip

Core Tip: This was a cross-sectional study conducted on patients with lower gastrointestinal symptoms who underwent colonoscopy at a tertiary hospital in Vietnam. Sessile serrated lesions (SSLs) were diagnosed on histopathology according to the 2019 World Health Organization classification. BRAF mutation analysis was performed using the Sanger DNA sequencing method. There were 2489 patients, with a mean age of 52.1 years. The prevalence of SSLs was 4.2%. In the multivariate analysis, factors significantly associated with SSLs were age ≥ 40, male sex, diabetes mellitus, and hypertension. The rate of BRAF mutations in SSLs was 35.5%.