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World J Clin Oncol. Feb 24, 2024; 15(2): 195-207
Published online Feb 24, 2024. doi: 10.5306/wjco.v15.i2.195
Deregulation of interferon-gamma receptor 1 expression and its implications for lung adenocarcinoma progression
Angeles C Tecalco-Cruz, Karen H Medina-Abreu, Enrique Oropeza-Martínez, Jesus Zepeda-Cervantes, Aleida Vázquez-Macías, Marina Macías-Silva
Angeles C Tecalco-Cruz, Karen H Medina-Abreu, Enrique Oropeza-Martínez, Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, CDMX 03100, Mexico
Jesus Zepeda-Cervantes, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, CDMX 04510, Mexico
Aleida Vázquez-Macías, Colegio de Ciencias y Humanidades, Universidad Autónoma de la Ciudad de México, CDMX 03100, Mexico
Marina Macías-Silva, Instituo de Fisiología Celular, Universidad Nacional Autónoma de México, CDMX 04510, Mexico
Author contributions: Tecalco-Cruz AC planned and participated in the research, organization of this article, and wrote the manuscript; Medina-Abreu KH, Oropeza-Martínez E, Zepeda-Cervantes J, Vázquez-Macías A, and Macías-Silva M participated in the research and wrote some parts of the manuscript; Tecalco-Cruz AC, Medina-Abreu KH, and Oropeza-Martínez E prepared some figures for this article; All authors revised the final manuscript.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Angeles C Tecalco-Cruz, PhD, Full Professor, Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, Colonia Del valle, San Lorenzo 290, Mexico 03100, Mexico. angeles.tecalco@uacm.edu.mx
Received: December 15, 2023
Peer-review started: December 15, 2023
First decision: December 22, 2023
Revised: January 5, 2024
Accepted: January 30, 2024
Article in press: January 30, 2024
Published online: February 24, 2024
Processing time: 66 Days and 18.4 Hours
Core Tip

Core Tip: IFNGR1 is a transmembrane receptor required for interferon-gamma (IFN-γ) signaling. IFNGR1 expression is deregulated in lung adenocarcinoma, affecting IFN-γ signaling to promote cancer progression and reduce antiviral responses. Thus, the status of IFNGR1 expression may be critical in the detection of this cancer, and the restoration of its homeostasis may help control tumor progression and improve defense against viral infections.