Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Oct 24, 2024; 15(10): 1359-1365
Published online Oct 24, 2024. doi: 10.5306/wjco.v15.i10.1359
Vaginal clear cell adenocarcinoma in Herlyn-Werner-Wunderlich syndrome: A case report
Xian-Gao Lei, Heng Zhang
Xian-Gao Lei, Heng Zhang, Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education; West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Lei XG and Zhang H contributed to manuscript writing and editing, Lei XG and Zhang H contributed to data collection; Lei XG and Zhang H contributed to data analysis; Zhang H contributed to conceptualization and supervision; all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Heng Zhang, MD, PhD, Associate Professor, Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education; West China Second University Hospital, Sichuan University, No. 20 South Renmin Road, Chengdu 610041, Sichuan Province, China. mazy6121981@163.com
Received: April 26, 2024
Revised: September 14, 2024
Accepted: September 19, 2024
Published online: October 24, 2024
Processing time: 155 Days and 12.2 Hours
Core Tip

Core Tip: Cervico-vaginal adenocarcinomas in patients with Herlyn-Werner-Wunderlich (HWW) syndrome are extremely rare. The present case and a literature review of this rare condition, indicate that patients with HWW syndrome may have a higher risk of developing cervico-vaginal adenocarcinomas, compared to the general female population. These cancers typically occur on the obstructed side, making them occult and difficult to detect. Therefore, it is crucial for patients with HWW syndrome to undergo septum resection upon diagnosis or, at a minimum, have regular imaging evaluations of the cervix and vagina, to facilitate early detection and management.