Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Oct 24, 2024; 15(10): 1293-1308
Published online Oct 24, 2024. doi: 10.5306/wjco.v15.i10.1293
Banxia xiexin decoction prevents the development of gastric cancer
Guo-Xiu Zu, Ke-Yun Sun, Xi-Jian Liu, Ji-Qin Tang, Hai-Liang Huang, Tao Han
Guo-Xiu Zu, Ke-Yun Sun, Xi-Jian Liu, Tao Han, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China
Ji-Qin Tang, Hai-Liang Huang, School of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China
Co-corresponding authors: Hai-Liang Huang and Tao Han.
Author contributions: Zu GX and Sun KY contributed to methodology, investigation, writing, review and editing; Liu XJ contributed to visualization, validation, writing, review and editing; Zu GX writing the original draft, data curation; Sun KY contributed to software, and formal analysis; Tang JQ contributed to resources and writing, review editing; Huang HL contributed to supervision, funding acquisition, writing, review and editing; Han T contributed to funding acquisition, conceptualization, writing review, and editing; Huang HL and Han T contributed equally to the study as co-corresponding authors; All authors have reviewed and approved the final version of the manuscript.
Supported by the Key Program of Shandong Province, China, No. 2016CYJS08A01-6.
Institutional review board statement: This study was exempted by the Ethics Committee of Shandong University of Traditional Chinese Medicine due to its not involving human subject research.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Center of Experiment, Shandong University of Traditional Chinese Medicine, IACUC protocol: No. SDUTCM20230828016.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The original RNA-seq data used in this paper has been uploaded to NCBI database (https://www.ncbi.nlm.nih.gov/).
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Liang Huang, Doctor, MD, PhD, Dean, School of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, No. 4655 Daxue Road, Jinan 250355, Shandong Province, China. 1615080865@qq.com
Received: June 13, 2024
Revised: August 9, 2024
Accepted: August 23, 2024
Published online: October 24, 2024
Processing time: 107 Days and 21.5 Hours
Core Tip

Core Tip: Based on the clinical efficacy of traditional Chinese medicine banxia xiexin decoction (BXD) in the prevention and treatment of gastric cancer, this paper explored the drug composition and drug authenticity of BXD based on Ultra-performance liquid chromatography tandem quadrupole electrostatic field orbitrap mass spectrometry technology, predicted the molecular mechanism of BXD in the treatment of gastric cancer based on network pharmacology and transcriptomics sequencing, and verified its molecular mechanism by combining in vivo and in vitro experiments.