Clinical and Translational Research
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jan 24, 2024; 15(1): 62-88
Published online Jan 24, 2024. doi: 10.5306/wjco.v15.i1.62
Identification of the key genes and mechanisms associated with transcatheter arterial chemoembolisation refractoriness in hepatocellular carcinoma
Jie-Zhuang Huang, Jian-Di Li, Gang Chen, Rong-Quan He
Jie-Zhuang Huang, Rong-Quan He, Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Jian-Di Li, Gang Chen, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Huang JZ and Li JD took part in data collection, statistical analysis, interpretation and paper drafting; He RQ and Chen G were responsible for study design, statistical analysis guidance and paper correction.
Supported by Guangxi Higher Education Undergraduate Teaching Reform Project, No. 2021JGA142; Guangxi Educational Science Planning Key Project, No. 2022ZJY2791; Guangxi Medical University Education and Teaching Reform Project, No. 2021XJGA02; and Guangxi Zhuang Autonomous Region Health Commission Self-financed Scientific Research Project, No. Z20201147.
Institutional review board statement: The study did not involve any human or animal related experiments, so no statement of ethics will be provided.
Informed consent statement: The letter is to state that “informed consent” is not apply for our manuscript because the data of this study are from the public database TCGA, GEO and GTEx database.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: The datasets analysed in this study are publicly available in the TCGA (https://portal.gdc.cancer.gov/), GEO (https://www.ncbi.nlm.nih.gov/geo/) and GTEx (https://gtexportal.org/home/) databases.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rong-Quan He, MD, PhD, Doctor, Researcher, Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. herongquan@gxmu.edu.cn
Received: October 23, 2023
Peer-review started: October 23, 2023
First decision: November 23, 2023
Revised: December 12, 2023
Accepted: December 28, 2023
Article in press: December 28, 2023
Published online: January 24, 2024
Processing time: 91 Days and 12.6 Hours
Core Tip

Core Tip: This is a study that explored the key genes and mechanisms related to transcatheter arterial chemoembolisation (TACE) refractoriness in hepatocellular carcinoma. Through the combination of tissue microarrays and RNA-seq with single-cell RNA sequencing, the TACE refractoriness-related genes were identified and five key genes (DLGAP5, KIF20A, ASPM, KIF11 and TPX2) associated with TACE refractoriness were revealed. The TACE refractoriness-related genes were found to mainly express in hepatocytes and embryonic stem cells. Hepatocytes providing ligands had the strongest interaction with embryonic stem cells as receptors providers.