Clinical and Translational Research
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jan 24, 2024; 15(1): 32-44
Published online Jan 24, 2024. doi: 10.5306/wjco.v15.i1.32
Scinderin promotes glioma cell migration and invasion via remodeling actin cytoskeleton
Xin Lin, Zhao Zhao, Shu-Peng Sun, Wei Liu
Xin Lin, Zhao Zhao, Shu-Peng Sun, Wei Liu, Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300000, China
Author contributions: Lin X designed the research study; Lin X, Zhao Z, Sun S, and Liu W performed the research; Zhao Z and Sun S contributed new reagents and analytic tools; Lin X analyzed the data and wrote the manuscript; All authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Tianjin Huanhu Hospital.
Informed consent statement: All study participants or their legal guardians provided informed written consent about personal and medical data collection before study enrollment.
Conflict-of-interest statement: The authors have no relevant financial or non-financial interests to disclose.
Data sharing statement: The mRNA expression and clinical data of glioma analyzed during the current study are available on the GEPIA database (http://gepia.cancer-pku.cn/) and CGGA) database (http://www.cgga.org.cn/). The protein expression of glioma analyzed in this study is also available on the UALCAN database (https://ualcan.path.uab.edu/). Other datasets during and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin Lin, PhD, Associate Chief Physician, Department of Neurosurgery, Tianjin Huanhu Hospital, No. 6 Jizhao Road, Jinnan District, Tianjin 300000, China. xnln69@aliyun.com
Received: September 8, 2023
Peer-review started: September 8, 2023
First decision: October 17, 2023
Revised: November 20, 2023
Accepted: December 19, 2023
Article in press: December 19, 2023
Published online: January 24, 2024
Processing time: 136 Days and 21.9 Hours
Core Tip

Core Tip: Actin dynamics-related protein scinderin (SCIN) was found to be significantly upregulated in glioma, and high SCIN expression was associated with advanced tumor grade and wild-type isocitrate dehydrogenase. Furthermore, silenced-SCIN cells exhibited decreased proliferation, migration, and invasion. Besides, knockdown of SCIN inhibited RhoA/focal adhesion kinase signaling to promote F-actin depolymerization in glioma cells.