Retrospective Cohort Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Apr 24, 2023; 14(4): 179-189
Published online Apr 24, 2023. doi: 10.5306/wjco.v14.i4.179
Interaction between age and gender on survival outcomes in extramedullary multiple myeloma over the past two decades
Ayrton I Bangolo, Pierre Fwelo, Chinmay Trivedi, Sowmya Sagireddy, Hamed Aljanaahi, Auda Auda, Maryama Mohamed, Sonia Onyeka, Miriam Fisher, Jyoti Thapa, Erwin J Tabucanon, Lyuben Georgiev, Annetta Wishart, Shilpee Kumari, Conrad Erikson, Mary Bangura, Orent Paddy, Rashmi Madhukar, Eugenio L Gomez, Joshua Rathod, Mansi Naria, Basel Hajal, Mohammad Awadhalla, David Siegel, Harsh Parmar, Noa Biran, David H Vesole, Pooja Phull, Simcha Weissman
Ayrton I Bangolo, Chinmay Trivedi, Sowmya Sagireddy, Hamed Aljanaahi, Auda Auda, Maryama Mohamed, Sonia Onyeka, Miriam Fisher, Jyoti Thapa, Erwin J Tabucanon, Lyuben Georgiev, Annetta Wishart, Shilpee Kumari, Conrad Erikson, Mary Bangura, Orent Paddy, Rashmi Madhukar, Eugenio L Gomez, Joshua Rathod, Mansi Naria, Basel Hajal, Mohammad Awadhalla, Simcha Weissman, Department of Medicine, Palisades Medical Center, North Bergen, NJ 07047, United States
Pierre Fwelo, Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth School of Public Health, Houston, TX 77204, United States
David Siegel, Harsh Parmar, Noa Biran, David H Vesole, Pooja Phull, Division of Myeloma, John Theurer Cancer Center, Hackensack, NJ 07601, United States
Author contributions: Bangolo AI searched the literature, wrote, and revised the manuscript; Fwelo P extracted and analysed the data, revised, and edited the manuscript; Trivedi C, Sagireddy S, Aljanaahi H, Auda A, Mohamed M, Onyeka S, Fisher M, Thapa J, Tabucanon EJ, Georgiev L, Wishart A, Kumari S, Erikson C, Bangura M, Paddy O, Madhukar R, Gomez EL, Rathod J, Naria M, Hajal B, Awadhalla M, Siegel D, Parmar H, Biran N, and Vesole DH revised and edited the manuscript; Phull P and Weissman S revised and approved the final version and are the article’s guarantors; All authors certify that they contributed sufficiently to the intellectual content and data analysis; Each author has reviewed the final version of the manuscript and approved it for publication.
Institutional review board statement: The study protocol was reviewed by the Ethics Committee at Palisades Medical Center and the need for IRB approval was waived as the SEER database is a public-use dataset.
Informed consent statement: The Surveillance, Epidemiology, and End Results (SEER) database was a public-use dataset, of which the informed consent was waived.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data used and/or analyzed in this study are available in the Surveillance, Epidemiology, and End Results (SEER) Database of the National Cancer Institute (http://seer.cancer.gov).
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ayrton I Bangolo, MBBS, MD, Doctor, Department of Medicine, Palisades Medical Center, 7600 River Road, North Bergen, NJ 07047, United States. ayrtonbangolo@yahoo.com
Received: December 17, 2022
Peer-review started: December 17, 2022
First decision: February 20, 2023
Revised: February 20, 2023
Accepted: March 17, 2023
Article in press: March 17, 2023
Published online: April 24, 2023
Processing time: 124 Days and 18.5 Hours
Core Tip

Core Tip: Very little is known about extramedullary multiple myeloma (EMM), owing to its rarity and scarcity of data on the subject. So far it was found that advanced age was the single most important prognostic value for poor outcome in EMM. However, how age interacts with gender to affect mortality in EMM remains unknown. We found that age did not interact with gender to affect mortality in EMM.