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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Feb 24, 2023; 14(2): 81-88
Published online Feb 24, 2023. doi: 10.5306/wjco.v14.i2.81
Published online Feb 24, 2023. doi: 10.5306/wjco.v14.i2.81
Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review
Shi-Xun Ma, Hui Cai, Tian-Kang Guo, Lei-Sheng Zhang, Department of General Surgery, Gansu Provincial Hospital, Lanzhou 73000, Gansu Province, China
Li Li, Scientific Research Division, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China
Lei-Sheng Zhang, Key Laboratory of Radiation Technology and Biophysics, Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui Province, China
Author contributions: Ma SX, and Li L wrote the paper; Zhang LS, Cai H, and Guo TK performed the data collection; All authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lei-Sheng Zhang, PhD, Professor, Department of General Surgery, Gansu Provincial Hospital, No. 204 West Donggang RD, Lanzhou 730000, Gansu Province, China. leisheng_zhang@163.com
Received: September 20, 2022
Peer-review started: September 20, 2022
First decision: November 28, 2022
Revised: December 13, 2022
Accepted: February 7, 2023
Article in press: February 7, 2023
Published online: February 24, 2023
Processing time: 153 Days and 18.2 Hours
Peer-review started: September 20, 2022
First decision: November 28, 2022
Revised: December 13, 2022
Accepted: February 7, 2023
Article in press: February 7, 2023
Published online: February 24, 2023
Processing time: 153 Days and 18.2 Hours
Core Tip
Core Tip: Advanced colorectal tumors are poorly treated, and immunotherapy has improved these patients’ outcomes. However, cold colorectal tumors are less likely to trigger a robust immune response and tend to suppress it. To address this phenomenon, we discuss the role of the tumor microenvironment, immune targets, and immune cells in the treatment of cold colorectal tumors.