Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Dec 24, 2023; 14(12): 570-583
Published online Dec 24, 2023. doi: 10.5306/wjco.v14.i12.570
Update on current diagnosis and management of anaplastic thyroid carcinoma
Efstathios T Pavlidis, Ioannis N Galanis, Theodoros E Pavlidis
Efstathios T Pavlidis, Ioannis N Galanis, Theodoros E Pavlidis, 2nd Propedeutic Department of Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54642, Greece
Author contributions: Pavlidis ET, Galanis IN, and Pavlidis TE analyzed data, and reviewed; Pavlidis TE designed research, contributed new analytic tools; Pavlidis ET performed research and wrote the paper.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Theodoros E Pavlidis, Doctor, PhD, Emeritus Professor, Surgeon, 2nd Propedeutic Department of Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki 54642, Greece. pavlidth@auth.gr
Received: October 5, 2023
Peer-review started: October 5, 2023
First decision: November 9, 2023
Revised: November 9, 2023
Accepted: December 1, 2023
Article in press: December 1, 2023
Published online: December 24, 2023
Processing time: 77 Days and 19.1 Hours
Core Tip

Core Tip: Anaplastic thyroid carcinoma is uncommon but one of the most lethal neoplasms. The optimal management remains unclear. The addition of novel targeted therapy and immunotherapy to the traditional management of surgery, radiation and chemotherapy has improved the outcomes. Multimodality management and the emerging use of individualized treatment based on novel therapeutic agents offers promising results. However, further research efforts involving the molecular microenvironment and biological drivers should be made.