Prakash A, Khalid F, Alalwan A, Bader H, Du D, Meghal T. Calcitriol induced hypercalcemia - a rare phenomenon in lung cancer: A case report. World J Clin Oncol 2023; 14(11): 544-548 [PMID: 38059187 DOI: 10.5306/wjco.v14.i11.544]
Corresponding Author of This Article
Farhan Khalid, MD, Chief Physician, Department of Internal Medicine, Monmouth Medical Center, 200 Second Avenue, Long Branch, NJ 07740, United States. farhan.khalid.md@gmail.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Nov 24, 2023; 14(11): 544-548 Published online Nov 24, 2023. doi: 10.5306/wjco.v14.i11.544
Calcitriol induced hypercalcemia - a rare phenomenon in lung cancer: A case report
Amulya Prakash, Farhan Khalid, Ahmad Alalwan, Husam Bader, Doantrang Du, Trishala Meghal
Amulya Prakash, Department of Internal Medicine, Haywood Regional Medical Center, Clyde, NC 28721, United States
Amulya Prakash, Farhan Khalid, Ahmad Alalwan, Husam Bader, Doantrang Du, Department of Internal Medicine, Monmouth Medical Center, Long Branch, NJ 07740, United States
Trishala Meghal, Department of Hematology-Oncology, Monmouth Medical Center, Long Branch, NJ 07740, United States
Author contributions: Alalwan A conceived the idea, did the literature search, managed the case on medical floor, contributed to case presenrtation and the introduction; Khalid F and Bader H contributed the discussion; Du D and Meghal T edited and revised the manuscript.
Informed consent statement: Informed consent was obtained by the patient.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Farhan Khalid, MD, Chief Physician, Department of Internal Medicine, Monmouth Medical Center, 200 Second Avenue, Long Branch, NJ 07740, United States. farhan.khalid.md@gmail.com
Received: July 26, 2023 Peer-review started: July 26, 2023 First decision: September 4, 2023 Revised: September 20, 2023 Accepted: October 23, 2023 Article in press: October 23, 2023 Published online: November 24, 2023 Processing time: 119 Days and 3.6 Hours
Core Tip
Core Tip: Our case report illuminates a rare mechanism of hypercalcemia in lung malignancies, characterized by elevated calcitriol. Despite its rarity, it sheds light on the pathophysiology of hypercalcemia in solid malignancies, notably lung cancers. To the best of our knowledge, this is the first documented case in medical literature to present this mechanism. Moreover, the successful management of this condition with bisphosphonates highlights the potential efficacy of this treatment approach for future cases involving similar symptoms. By emphasizing this novel observation, our report contributes to the expanding body of knowledge regarding hypercalcemia in lung cancers and paves the way for the development of novel therapeutic strategies for the treatment of such cases.
